Archive for the ‘Steroids’ Category

Proviron Profile

Proviron (mesterolone) is basically an orally active DHT (Dihydrotestosterone) preparation. For comparision, we can think of some other orally prepared DHT compounds like Winstrol, Anavar, etc& Those both act very similarly in mechanism to Proviron, but a more accurate way to think of this compound is as something like “Oral Masteron.” As I´m sure you noticed, their anabolic/androgenic ratio is very similar.Remember, DHT is 3 to 4 times as androgenic as testosterone and is, of course, incapable of forming estrogen. Also, Proviron is quite unique in that a simple look at it´s 4-ring structure will show us that it is not going to be too liver toxic, since it is not c17-Alpha-Alkylated, as many orals are& this modification (lacking in Proviron) makes drugs more liver toxic. Proviron has a 1-metyhl group added, instead. Looks pretty great on paper, right? Well, as usual, things tend to look better on paper than they do in the body. Your body has a negative feedback loop which prevents your body from having too much DHT floating around(if you´ve been paying attention up to now from reading my other stuff, you already know this). An excess of DHT will eventually be changed into another (largely not anabolic) compound. (more…)

Basic Guide To IGF-LR3

What is it? And why is the difference between huIGF-1 and LR3 IGF-1?

IGF-1 stands for insulin like growth factor. IGF-I is the *****ry protein involved in responses of cells to growth hormone (GH): that is, IGF-1 is produced in response to GH and then induces cellular activities. One such example is muscle growth or hyperplasia
This compound also makes the human body more sensitive to insulin. It is the most potent growth factor found in the human body. IGF-1 causes muscle cell hyperplasia, which is an actual splitting and forming of new muscle cells, this is a good thing.

LR3 IGF-1
Long Recumbent 3 IGF-1, which is an 83 amino acid analog of human IGF-1 sequence with the substitution of an arg for the glu at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus (hence the long).

HuIGF-1
It has a 70 amino acid string. It is very short lived in the body (half life of probably around 10-15 minutes). This type of IGF-1 is very useful if you are seeking local site growth. Since it is so short lived, little of the IGF-1 makes it to other tissues and IGF-1 receptors in the body. The way to inject this is immediately post work out into the muscle that you wish to have local site growth.

This coupled with PGF2a and TNE would do wonders for site specific growth IMO.

Usage
It needs to be shot PWO. Most shoot bilaterally into the muscle that was worked.

Stacking- because LR3 increases hyperplasia it is best when used in conjunction of other AAS.
The ideal situation would be to inject twice ED due to the life of LR3. If this isnt feasible PWO will suffice, and suffice well.
If you are on your off day, in the AM is best. It will help fight catabolism.
If you add insulin to your LR3, be careful. LR3 will make you more sensitive to the effects that insulin has on you. So raise your PWO carb intake to accommodate the added LR3.

If you have never ran insulin before, DO NOT add it with LR3.

What can I expect?
First off you can expect to drop a little BF if your diet is good. LR3 seems to burn off fat.
You can expect an increase in hunger, this is awesome when bulking. That though can be controlled while cutting.
Another thing to remember is hyperplaisa, once again the forming of new muscle cells, thus more size. Strength will go up along with the new muscle mass.
You can expect great pumps. For some people so bad it hurts… you be the judge. I for one have never got pumps that hurt like that… for me personally I feel more pumps with insulin.

Dosing For LR3
The general consensus for dosing LR3 seems to be 40mcg to 60mcg. For no longer than 5 weeks. Do not exceed 100mcg. The average user should have no reason to ever come close to that dose. Some people shoot everyday, some just PWO. So on the days you do not work out the best thing to do is shoot whenever you wake up this helps maintain constant blood levels and helps fight of catabolism.

The first time user should just use 40mcg on PWO days only. This way you can use 40mcg for 5 weeks assuming you have just one MG of LR3. It is a great starting dose that will get you results. But if you have used 40mcg in the past and didnt see the results you wanted, try 60mcg.

A great way to run a cycle that includes IGF would be this-
weeks 1-12 test enanthate E3D 500-750mg a week
Weeks 1-4, 15-19* 40mcg of LR3 ED
PCT 14-18

*IMO I do not feel that its needed the first week of PCT, if my weight falls off it does in weeks 2-3, so I want to aleviate that problem.

Dosing For huIGF

This is about the same as LR3, this is stritcly my opinion based on what I have gatherd and read. As there is next to no information on this. So from what I know about it, this is how Id/do/will use it.
PWO with 30-40mcg into each muscle that was worked. 20-30 min later, repeat. Do this for 4 times. for a total of 120-160mcg
And if I were using this Id use it with humalog. The insulin will remain active for over and hour after the IGF was injected. So this will get all the possible gains from it that you could.

How to figure out dosing

Ok I get, I should use 40mcg…. but how do I figure that out?

1mg = 1000mcg… assuming there is 1ml of liquid we can say that 1ml = 1000mcg and also = 100units…
So 2 units = 20 mcg
The best way to measure this is to use an insulin syringe. You can get away with a 1cc syringe but I prefer to use the .5cc or even the .33cc ones. They measure out each unit, so when you are measuring two units it is much easier on the smaller pin. While the 1cc syringe is fine, it is mesured out by two IU at a time. So one “tick” on the 1cc is 2iu, the .5cc each “tick” is one IU.

Wow so you mean you’re telling me I shoot 4iu of this stuff? What if I do not get it all out of there ?

I thought you would never ask. I have found the best way to get it and even measure my LR3 is like this. First draw out 30iu of B12 or BW (bacteriostatic water) on the dot. Then draw your LR3 out for a total of 34iu. This means you have 4iu of LR3 in the end of your syringe. Shoot out all of it and that way you can be sure all of the LR3 is out and into your desired muscle of choice.

Reconstitution.
RedBaron has a great thread on reconstitution with AA (acetic acid), check it out here.
But just about always you do not have to worry about reconstituting it yourself. All of the manufacturers usually suspend their LR3 in either BA or AA for you.

Storage, Taken from MR
The stability of a liquid solution of LR3IGF-I was monitored for a period of two years at storage conditions of -20 C, +4 C, +22 C, and +37 C. The final concentration of LR3IGF-I was in acetic acid. At various time points, samples were taken and compared to a lyophilized control (stored at 4 C). Listed below are the stability results for each respective storage condition.

Storage Condition: -20 C (-4 F)
Biological Potency No Change up to 2 years
Immunological Activity No Change up to 2 years
Mobility of Protein No Change up to 2 years
Elution Profile by reversed phased HPLC No Change up to 2 years

Storage Condition: +4 C (39.2 F)
Biological Potency No Change up to 2 years
Immunological Activity No Change up to 2 years
Mobility of Protein No Change up to 2 years
Elution Profile by reversed phased HPLC No Change up to 2 years

Storage Condition: +22 C (71.6 F)
Biological Potency No Change up to 2 years
Immunological Activity No Change up to 2 years
Mobility of Protein No Change up to 2 years
Elution Profile by reversed phased HPLC No Change up to 2 years

Storage Condition: +37 C (98.6 F)
Biological Potency No Change up to 1 year
Immunological Activity No Change up to 1 year
Mobility of Protein No Change up to 1 year
Elution Profile by reversed phased HPLC No Change up to 1 year

In conclusion
There is no significant difference in the potency of LR3IGF-I associated with the storage of the liquid formulation when stored at this range of temperatures. There is no evidence for loss of biological activity at any of the tested temperatures when stored as a liquid product. As you can see IGF can be quite stable for even a year at room temp, but if you want to keep it around for a while stick it into the fridge. So IMO the best way to store LR3 that is suspended in BA is in the freezer. The BA wont allow it to freeze. And if you have it suspended in AA, store it in the fridge.

Mechano Growth Factor (MGF) Info

Let’s start with an explanation of Mechano Growth Factor (MGF) and what it does. The muscle insulin-like growth factor-I (IGF-I) mRNA splice variant (IGF-IEc) has been identified in rodents. IGF-IEc, also called mechano growth factor (MGF) has been found to be up-regulated by exercise or muscle damage. Growth hormone (GH) is the principal regulator of IGF-I expression in several tissues including the skeletal muscle.

MGF is derived from IGF-I but its sequence differs from the systemic IGF-I produced by the liver. MGF is expressed by mechanically overloaded muscle and is involved in tissue repair and adaptation. It is expressed as a pulse following muscle damage and is apparently involved in the activation of muscle satellite (stem) cells. These donate nuclei to the muscle fibres that are required for repair and for the hypertrophy processes which may have similar regulatory mechanisms (Goldspink, G., 2005, p. 22).

The C-terminal peptide MGF, an alternatively spliced variant IGF-1, was found to function independently from the rest of the molecule. At any rate, IGF-I exists in multiple isoforms (tissue-specific proteins of functional and structural similarity). One isoform, which differs from the systemic or liver type, happens to be particularly sensitive to mechanical signals such as the gamut of exercise overload. MGF is a local splice variant of IGF-I produced by damaged or loaded skeletal muscle (Dluzniewska J, et al.., 2005 p. 1).

The physiological function of MGF was studied using an in vitro cell model. Unlike mature IGF-I, the distinct E domain of MGF inhibits terminal differentiation whilst increasing myoblast proliferation. Blocking the IGF-I receptor with a specific antibody indicated that the function of MGF E domain is mediated via a different receptor. The results provide a basis for localized tissue adaptation and helps explain why loss of muscle mass occurs in the elderly and in dystrophic muscle in which MGF production is markedly affected (Yang SY, Goldspink G., 2002, p. 156-60).

Ok, enough of the science. I am sure your brain is probably hurting after reading that, I know mine was. In really simple terms, MGF is a variant of IGF-1, an isoform that is particularly sensitive to muscle trauma (weight training) and is essential for repair and growth of new cells, similar in manner to IGF-1. What you need to know is MGF triggers new cell growth or hyperplasia in rat testing, and since we as bodybuilders fancy ourselves as lab rats, it is currently the in vogue peptide by top amateurs and pro’s.

Well all of this sounds great but what is the catch? This is where we reach a cross-road, a potential problem with MGF. As great as MGF has been in clinical trials and rat studies, the fact is that injected MGF has a half life of minutes….yes minutes. So how are you going to make this work, besides injecting every hour or so of your waking day? The answer lies in a little known molecule protection agent knows as PEGylation.

So what is or PEGylation? In simple terms it is the process of attaching one or more chains of a substance called polyethylene glycol (PEG) to a protein molecule such as IGF or in this case MGF. Since the body does not react to PEG, it helps provide a protective barrier around an attached protein so it can survive in the body longer. This is highly beneficial for systemic products that must survive repeated attacks by enzymatic exposure. PEG is an inert non-toxic substance that can provide protection to amine groups since they are flexible and allow attachment by bioengineered processes to the receptor bearing cell. Finally a quick explanation of polyethylene glycol; Any of a family of high molecular weight compounds that can be liquid or wax-like in consistency and are soluble in water and in many organic solvents.

Polyethylene glycol itself does not react in the body and is very safe. PEG has been approved by the US Food and Drug Administration (FDA) as a base or vehicle for use in foods and cosmetics and in injectable, topical, rectal and nasal pharmaceutical formulations. The risk associated with current PEGylated drugs are due to the way the drug itself acts not the PEG.

PEGylation can improve dosing convenience of many small molecules by increasing bioavailability and reducing dosing frequency. PEGylation also increases the amount of time the cell sits at the target site. This can be both good and bad. It is good because it increases the drug concentration, and with a longer time at the site, there is more chance of uptake by the cell. The bad news is that while it is sitting at the cell, there is increased risk of damage by enzymes that attack the cell. This is a double-edge sword that is a necessary evil; you must protect the molecule but at the same time increase the risk factor of damage due to longer exposure times at the target cell. As a result of the increased time at the cell, the optimal drug concentration can be achieved with less frequent dosing; a significant benefit to bodybuilders who are usually using poly-pharmacy at its finest.

PEGylated MGF is systemic in nature, meaning that the method of administration is not important. Most people are using MGF in a fashion similar to IGF, meaning they inject the peptide intramuscularly in recently trained muscle groups, hoping for an increase in cell repair and proliferation of new cells. While this thinking is optimistic at best, there is no research that would support site specific injections being beneficial for localized growth. This is a myth that has purveyed aas and peptide use for years. At this time, the literature and lab studies support subcutaneous injection, using small gauge insulin syringes.

Obviously there are no human research trials at this time; the peptide is still in research phases. Bodybuilder use at this time is all by trial and error. One company that currently carries MGF has conducted their own research trials, using test participants from underground steroid boards who are providing feedback in weekly intervals. While this is hardly a controlled environment and may have to many variables to accurately assess the product, at least it is a start.

I have also been conducting my own research, on myself and my clients, who often refer to themselves as Gavin’s guinea pigs. As with most peptides, more is not better. Smaller doses with less frequent injection schedules have proven to be optimal. I personally have been using 200mcg injected sub-q, two times per week. I have had my clients try 100mcg, two times per week, three times per week, daily, etc. So far the best results have been my personal method, 200mcg, two times per week.

Elite athletes are experiencing incredible body fat loss, increased pumps, fullness, and vascularity. I was able to gain 6 pounds of lean mass and lose 4.2% body fat in 4 weeks of use. I kept using it for weeks 5 and 6 but with no further gains or body fat loss. It seems that MGF stalls out at the 4 week mark, my theory being that much like with media grade IGF-1 LR3, the cells reach super saturation and cannot process any further uptake of the peptide sequence. It is possible to bypass this saturation, but it will take some time to work out the differential nature of the timing, much like I had to do with IGF-1 LR3, where I have now found ways to take it for up to 20 weeks with little to no cell down-regulation.

At this time all use and injection schedules are by word of mouth, sometimes by erroneous information on underground boards. Proper use of MGF is merely by speculation; it will take some time to sort out the best method of administration, although with the ever changing world of science, where nothing ever stands still, it may take years to sort out optimal dosing schedules. Even with such stable peptide structures as growth hormone that have had years of research, new information is always being studied, and I speculate that it will with all peptides.

By Gavin Kane

Testosterone Propionate

Androgenic: 100
Anabolic: 100
Standard: standard
Chemical Names:
4-androsten-3-one-17beta-ol
17beta-hydroxy-androst-4-en-3-one
Estrogenic Activity: moderate
Progestational Activity: low
Average Dose: 50-200 mg/EOD [for males] and 25-50 every 5 to 7 days [for females]

Testosterone propionate is a commonly manufactured, oil¬based injectable testosterone compound. The added propionate ester will slow the rate in which the steroid is released from the injection site, but only for a few days. Testosterone propionate is therefore comparatively much faster acting than other testosterone esters such as cypionate or enanthate, and requires a much more frequent dosing schedule. While cypionate and enanthate are injected on a weekly basis, propionate is generally administered (at least) every third day. Figure one illustrates a typical release pattern after injection. As you can see, levels peak and begin declining quickly with this ester of testosterone. To make this drug even more uncomfortable to use, the propionate ester can be very irritating to the site of injection. In fact, many sensitive individuals choose to stay away from this steroid completely, their body reacting with a pronounced soreness and low-grade fever that may last for a few days. Even the mild soreness that is experienced by most users can be quite uncomfortable, especially when taking multiple injections each week. The “standard” esters like enanthate and cypionate, which are clearly easier to use, are therefore much more popular among athletes.

Those who are not bothered by frequent injections will find that propionate is quite an effective steroid. As an injectable testosterone it is, of course, a powerful mass drug, capable of producing rapid gains in both much size and strength. At the same time the buildup of estrogen and DHT (dihydrotestosterone) will be pronounced, so typical testosterone-related side effects are to be expected. Bodybuilders generally consider propionate to be the mildest testosterone ester, and the preferred form of this hormone for dieting/cutting phases of training. Some will go so far as to say that propionate will harden the physique, while giving the user less water and fat retention than one typically expects to see with a testosterone like enanthate, cypionate or Sustanon. Realistically however, this is nonsense. The ester is removed before testosterone is active in the body, and likewise the ester cannot alter the activity of the parent steroid in any way, only slow its release. It all boils down to how much testosterone you are getting into your blood with each particular compound ¬otherwise there is no difference between them.

During a typical cycle one will see action that is consistent with other forms of testosterone. Users sensitive to gynecomastia may therefore need to addition an anti¬estrogen. Those particularly troubled may find that a combination of Nolvadex® and Proviron® works especially well at preventing/halting this occurrence (Arimidex or Femara are even more effective options, but are also more costly). Also unavoidable with a testosterone are androgenic side effects like oily skin, acne, increased aggression and body/facial hair growth. Those who may have a predisposition for male pattern baldness may also find that propionate will aggravate this condition. To help combat this we also have the option of adding Propecia®/Proscar® or Avodart®, which will reduce the buildup of DHT in many androgen target tissues. This will help minimize related side effects (particularly hair loss), although it offers us no guarantees. And as with all testosterone products, propionate will suppress endogenous testosterone production soon into the cycle. The use of a testosterone stimulating regimen of HCG and NolvadexlClomid® is, therefore, almost a requirement at the end of the cycle, in order to avoid enduring the dreaded hormonal crash.

The most common dosage schedule for this compound (men) is to inject 50 to 100mg, every 2nd or 3rd day. As with the more popular esters, the total weekly dosage would be in the range of 200-400mg. As with all testosterone compounds, this drug is most appropriately suited for bulking phases of training. Here it is most often combined with other strong agents such as Dianabol, Anadrol 50®, or Deca-Durabolin®,combinations that prove to be quite formidable. However, Propionate is sometimes also used with non-aromatizing anabolics/androgens during cutting or dieting phases of training, a time when its fast action and androgenic nature are also appreciated. Popular stacks include a moderate dosage of propionate with an oral anabolic like Winstrol® (15-35mg daily), Primobolan® (50-150mg daily), or oxandrolone (15-30mg daily). Provided the body fat percentage is sufficiently low, the look of dense muscularity can be notably improved (barring any excess estrogen buildup from the testosterone). We can further add a non-aromatizing androgen like trenbolone or Halotestin®, which should have an even more extreme effect on subcutaneous body fat and muscle hardness. With the added androgen content any related side effects will become much more pronounced.

Women who absolutely must use an injectable testosterone should only use this preparation. This is simply because blood levels are easier to control with it compared to other long-acting esters. Should virilization symptoms develop, one would not wish to wait the weeks needed for testosterone concentrations to fall after a shot of enanthate. The dosage schedule should also be more spread out, with injections coming every 5 to 7 days at most. Obviously, the dosage would be lower as well, generally in the range of 25mg per injection. Androgenic activity should be less pronounced with this schedule, giving blood levels time to sufficiently decrease before the drug is administered again. In order to further reduce any risks, the duration of this cycle should not exceed 8 weeks. Should a stronger anabolic effect be needed, a small amount of Durabolin® (Deca-Durabolin® if unavailable), Oxandrolone, or Winstrol® could be added. Of course, the risk of noticing virilizing effects from these drugs may increase, even with the addition of a mild anabolic. Since many of the masculinizing side effects of steroid use can be irreversible, it is very important for the female athlete to monitor the dosage, duration and incidence of side effects very closely.

Testosterone propionate is very abundant on the black market right now, perhaps more so than it was a couple of years ago. This probably has a lot to do with the fact that it is a very cheap steroid to manufacture next to some of the longer acting esters. In going over some of the more popular items circulating the black market at this time, I can offer the following observations.

Animal Power has a propionate product in Mexico called Propiotest 100. This is a 100mg/mL steroid, which comes in a 10mL multi-dose vial. The company uses several security checks on its injectable products, including a security holographic sticker with the company logo embedded in the image (see: Security Stickers). Be sure to look for these when shopping.

Quality Vet is making Propionat QV 100 in Mexico, which is another 100mg/mL preparation in a 10mL multi-dose vial. Just be sure to look for their holographic security sticker when shopping, which should assure a safe purchase.

Testosterona from Brovel in Mexico is still abundant. Brovel has been around for a long time, and has always delivered a quality product for an excellent price. Remember to look for the Brovel Hologram sticker to be sure you are getting the real thing, as there are a lot of fakes of this line floating around (not this product in particular though).

Ttokkyo has ceased operations in Mexico. This firm used
to make an excellent propionate product, but even old stock will be off the black market at this point. Avoid.

Testopro L/A from Loeffler in Mexico contains a whopping 250mg/mL, at least according to the label on this 10mL multi-dose vial. Loeffler products seem to have been hit or miss in quality lately though, and a previous test of this item in particular showed it to have a bit over 133mg of testosterone propionate in each mL. This is a little better than half of the label claim, which leaves us wondering if Loeffler has ever produced a true 250mg/mL testosterone propionate. Hopefully, I will have the opportunity to test some lots in the future to find out.

Testolic from Body Research is no longer being made, following a raid on their facilities last year. Currently the Body Research name is being used by counterfeiters in Eastern Europe, mostly to make products with questionable contents.

British Dragon also makes Testabol Propionate in Thailand, another export only item (you will not find it is pharmacies when shopping on vacation). The BD line is very hot right now, with a very good reputation. Note that the have stopped using hologram stickers on their injectable products. Instead, they are using a red or blue metallic foil inlay on their labels. Be sure the product name is also formed directly into the plastic on the flip off top, and once removed reveals a dragon logo directly in the rubber stopper.

BM Pharmaceuticals is a quasi-legit company in India that makes a brand of testosterone propionate called Testopin-100. As the name indicates, it contains 100mg/mL of steroid. It is packaged in both 1 mL glass ampules and 2mL multi-dose vials. Currently, fakes of this line are not much of a problem.

Jelfa makes Testosteronum Propionicum in Poland, which makes its way most often to the European black market (rarely to the U.S.). However, it only contains 25mg of steroid in each 1 mL ampule, so it doesn’t stack up much to the more popular 100mg/mL products here in the States.

Virormone is still manufactured in the U.K., most recently by the firm Nordic. These 2mL 100mg ampules are not extremely popular in the U.s., but do circulate here from time to time. The UK has been taking steroid distribution more seriously as of late, limiting greatly the supply of domestic drugs making it to the international black market.

No testosterone propionate products are being manufactured in the U.S. at this time, so avoid all such products on the black market.

Vetoquinol sells a propionate in Canada, called Anatest. This steroid used to be sold under the Sterivet label, which is not another company but the parent company of Vetoquinol. Anatest contains 100mg/mL of testosterone propionate in a 10ml vial, giving it a dosage and volume comparable to many of the higher dosed veterinary items on the black market. Combine this with the rigid standards of Canadian drug manufacturing (if you find a legitimate product), and Anatest starts looking like an excellent product if you come across it. Unfortunately, the firm doesn’t use any hologram or sophisticated security measures. Shop carefully.

How To Create The Perfect Cycle

How to create the perfect cycle for you

INTRO:
So you want to create the perfect cycle for yourself. So how do you go about this? Well there’s a lot of things you need to know before you can sit down and create yourself a perfect cycle.

The most important thing you need to know is what your EXACT goals are for THIS cycle. From here you can figure out exactly what steroids are right for you and at what dosages.

BASICS:
So what about steroids, ancillaries, and other drugs do you need to know? You need to know the basics of the most popular drugs available.

Steroids:
-Testosterone (Enan, Cyp, Prop, Sust, Omna)/Test
-Deca-Durabolin/Deca
-Equipose/EQ
-Dianabol/D-bol
-Winstrol/Winny
-Anadrol/Drol
-Halotestin/Halo
-Anavar/Var
-Tren/Fina
-Primobolan/Primo

Ancillaries:
-Nolvadex/Nolva (Tamoxifen)
-Arimidex/Arim (Anastrozole)
-Femera/Fem (Letrozole)
-Aromasin (Exemestane)
-Clomid
-HCG
-Proviron (technically a steroid, but oft considered an ancillary)
-Finasteride
-Bromocriptine/Bromo

Other BBing/Performance Enhancing Drugs:
-Clenbuterol/Clen
-Cytomel/Cynomel/T3
-DNP
-Insulin/Slin
-Human Growth Hormone/hGH/GH
-EPO

There are of course many other types of steroids, ancillaries and sports enhancing drugs, but they are extremely rare. I won’t go into a full discussion about each of the drugs above, but will just list properties of the drugs and state which steroids have those properties.

-Large Mass Steroids: Test, Deca, Drol, D-bol and to a lesser extent: EQ, Primo
-Strength Steroids: Test, Drol, D-bol, Tren and to a lesser extent: Halo, Var
-Steroids that have low/no aromatization: Drol, EQ, Primo, Halo, Var, Tren, Winny
-Steroids that raise red blood cell count: EQ, Drol and to a lesser extent: most others
-Low-Lean Mass Steroids: Winny, Halo, Var, Tren
-Steroids with direct fat-burning properties: Test, Tren, Var
-Mostly Androgenic Steroids: Halo, Methyltest
-Mostly Anabolic Steroids: Deca, EQ, Primo, Winny, Var
-Highly Anabolic Androgens: D-bol, Drol, Tren
-Mostly even Androgenic/Anabolic Steroids: Test
-Steroid most likely to cause aggression: Tren
-Liver Toxic Steroids: D-bol, Winny, Drol, Halo, Methyltest, Var
-Short Acting Steroids: Test Prop, D-bol, Winny, Drol, Halo, Var, Tren
-Long Acting Steroids: Test Enan, Test Cyp, Deca, EQ, Primo, Sust, Omna
-Progestins: Deca, Anadrol
-Prolactins: Tren
-Acts like an estrogen: Anadrol
-Anti-Progestin: Winny* (anecdotal evidence)
-Drugs for Mass (excluding AAS): Slin
-Drugs for Strength (excluding AAS): Slin, GH
-Anti-Aromatases: Arimidex, Femera, Aromasin, Proviron
-Anti-Estrogens: Nolvadex, Clomid
-Anti-Androgens: Finasteride
-Fat Burners: Clen, T3, DNP, GH
-Anti-Prolactin: Bromo
-Stimulates LH release: HCG
-Aids HPTA recovery: Clomid, Nolva, GH
-Drugs that increase red-blood cell count (excluding AAS): EPO, GH
-Drugs that raise IGF-1 (excluding oral AAS): Slin, GH

THEORY:
Ok so now that you know what drugs do what, we can begin to discuss what properties a cycle should have. From there we can begin to see how these drugs can be combined to form a “stack.” The idea behind the stack is to create a synergy between the drugs involved to give an effect that’s greater than the sum of the parts.

Mass Cycles:
These are cycles were all out mass is required. Here we give no consideration to fat gain, water gain or any of that stuff. We are just looking to pack on as much muscle as possible (don’t forget, water and fat are GOOD for muscle gains).

To get all out mass, we need to attack our system from all angles. We need steroids that are highly androgenic and highly anabolic. We need steroids that are known to pack on a lot of mass. In general, steroids that do not aromatize, do not activate the AR and do not pack on a lot of mass aren’t needed. For injectables we would rather have long acting esters than short ones, as the long acting esters tend to pool up in your blood and generally leave you with more hormone at any given point. For orals we prefer those that either aromatize heavily, or cause an explosion of mass by similar estrogenic properties. The use of orals is mainly to kick off the mass cycle, gives you near instant results and puts your body in a good anabolic state when the long acting esters kick in.

With all that said the best steroids for mass are: Test Enan, Test Cyp, Deca, D-bol and Drol. Advanced users can also use things like Insulin and GH.

Cutting Cycles:
Realize that with the exception of Test, Tren and Anavar, no steroid has a direct impact on fat burning. Even Test, Tren and Var have limited effects on fat burning. You shouldn’t go into a cutting cycle with the mindset of “These steroids are going to help me loose fat.” Instead you should think of the steroids as muscle sparring. Basically you’re using them to preserve the muscle that you have, while, diet, cardio and your true fat burners (like Clen, DNP and T3) work on the fat. All steroids listed above meet the first requirement; they will all help you retain muscle in a calorie deficient diet. However, if you are cutting you certainly do not want your steroids to be in the way either. Some steroids (drol) actually make it harder to loose fat. Others can bloat you up so bad that even with a low body fat percentage, most of your definition can be lost. So what we need here is steroids that are more androgenic than anabolic. We need steroids that have direct fat burning properties and steroids that do not aromatize heavily. If we do use a long acting ester, we would prefer to use one that doesn’t aromatize heavily, if the injectable does aromatize significantly, we would prefer to use a short acting ester as short acting esters don’t pool up, and an anti-aromatase would be a good idea.

Best fat burners: Clen and T3. Advanced users may also use DNP and GH

Best steroids for cutting: Test Prop, EQ, Primo, Tren, Winny, Halo, Proviron, Var

Sports/Performance Enhancing Cycles:
Now I can’t claim that I know what’s really best for a non-bodybuilding athlete. But I can take a guess and you guys that do participate in sports can probably figure it out given my explanations.

First let’s look at sports that require strength without increased mass. Obviously any “mass builder” is out the door. Any steroid that aromatizes heavily is not desirable here, as the extra water will certainly make you put on weight. Your best drugs for this purpose would be: Halo, Winny, Var and GH. If you can afford a few extra pounds (like in the offseason or what not), Tren would also be a good steroid.

Now let’s look at cycles for sports that require endurance. As we’ve discussed before, some steroids increase red blood cell count significantly; this equals better endurance performance. The best drugs to use for this purpose are EQ, GH and EPO. Because EPO can have such a drastic effect on red blood cell count, it is NOT recommended that you use it along with steroids.

POST-CYCLE THERAPY (PCT):
When you use any steroid, your HPTA will be suppressed. What this means is that your system is not producing any endogenous testosterone, which means you won’t have any hormone to help maintain your gains. What good is a cycle if you can’t keep your gains? So the key to cycling is to get your endogenous test back on track ASAP.

One thing that will hinder HPTA activation is excess estrogen, whether it is from aromatizable steroids used in your cycle or whether it be endogenous estrogen. Using anti-estrogens like Clomid and Nolva will help prevent this negative feedback.

When your body sends out LH (leutinizing hormone), it signals your testicles to begin producing test again. During your cycle, LH release will be suppressed and will remain suppressed for a few weeks after your cycle. HCG mimics LH and helps your testicles start producing testosterone. For our purposes we should view HCG as a “bridge” between your cycle and the time your LH returns to normal function. However, HCG when used to heavily or for too long will actually suppress natural test production so it can be counter productive.

Different cycles will suppress your HPTA to different degrees. Cycles including Deca and Fina will be more suppressive than cycles including Var and Primo. I don’t have the energy to design a post cycle therapy for each cycle, so I will post here a post cycle therapy program that should help you recover from any sane and sensible cycle.

Before we outline the universal post-cycle therapy, we need to define when a cycle officially ends. If you are using long acting esters, your cycle ends 2-3 weeks after you take your last shot of the long ester (I wont explain why, just accept it). If you are using ONLY short acting steroids OR your last shot of long acting steroids was over 3 weeks ago, and the only thing you’ve been running since then is short acting steroids, then your cycle officially ends the last day of administration of your steroids.

So given that, here is the universal post-cycle recovery program:

HCG
2 Weeks Before End of Cycle: HCG @ 1500IUs 3 times a week
1 Week Before End of Cycle: HCG @ 1500IUs 3 times a week
First Week Post-Cycle: HCG @ 1500IUs 2 times a week

Clomid
Day 1 Post Cycle: Clomid @ 300mg
Days 2-14: Clomid @ 100mg ED
Days 15-28: Clomid @ 50mg ED

Nolva
Days 1-28: Nolva @ 20mg ED

More advanced users can also experiment with GH, Slin and DNP.
Written by: Duanabol

How To Get Huge: THE RIGHT AND SAFE WAY!

Do you know how sick it makes me when guys say, “I have been using steroids for 6 months now and I still can’t grow?” This only makes me mad because it’s so easy to get big if you have the time and the energy to put into your body. It’s the same as everything else in life, you get what you give.

Training

Training is about 30% of the struggle but it is very important cause without it, you simply will not grow. The best advice I can give when it comes to the training part is that you have to keep your body guessing, which I can’t stress enough. Also, this is a life long journey and NOTHING will happen overnight. I like to split up my routine into one body part per day and switch it up every month in exercises, sometimes compound and sometimes basics,sometimes machines, and sometimes dumbbells. If you are still having trouble putting on mass(which is what you must do first), then you have to use all basic movements and utilize power-lifting exercises to reach your goal. The best mass builders are Bent-over rows for your back, dead-lifts for overall thickness in the hams and back, bench press for the chest, straight bar curls for the biceps, skull crushers for the triceps, squats for the legs, and military press for the shoulders. If your not using these exercises, you better start. Also remember to always take 2 days to rest and never over-train. This would be a good ideal split for beginner or intermediate:

Monday-Chest

Tuesday-Back

Wednesday-OFF

Thursday-Shoulders

Friday-Legs

Saturday-Biceps and Triceps

Sunday-OFF

GEAR

OK, now it would be stupid of me to say that you can get super huge without gear, and it’s just not possible. However, I would suggest that you take your training to the absolute maximum without drugs first, until you have reached your natural genetic potential. Most people will say you need all kinds of different drugs to get huge, which is not true at all, you will need all kinds of drugs if your planning on being a pro. To play it safe after you have decided to use drugs, keep it simple and I guarantee you that if you rely on YOU and your training and nutrition instead of the drugs, then you will have a much better bodybuilding regimen. Too many people out there are relying on drugs and not paying enough attention to their diet or their training. It’s very important that you only use one substance to start out with, testosterone would be a good choice. In order to get to the size in which we are talking then your gonna need it. The problem is that once your genetics have run out of room for growth than what comes next? This is when steroids are needed to continue on with your journey. Testosterone as your anabolic and deca or eq as your androgenic, this is all you will need and the dosages depend on how healthy you want to be.

Physicians

The only way to be positive that your staying healthy while taking steroids is to make sure you find a doctor that you trust. I found one and it took me a few years to do so, but now I trust him with my life and you should too. You will want to have regular blood tests done to make sure your liver is functioning properly as well as the other internal organs. Do not be afraid to tell your doctor whats going on, it’s the only way to help for him.

Sleep

Sleep is one of the most missed factors when it comes to growing. You grow when you sleep, and without it you will not grow! It’s that simple, estimated 6-8 hours of sleep per night is normal for optimal growth. So make sure you get that nap in, it will benefit you in the long run.

Diet

Diet is the most important factor when it comes to getting big. Your gonna need to pack in as much protein as possible and also figure out what your daily recommended allowance is. Once you find how many calories you need per day just to maintain, then you need to add 500 calories to that, and make sure you keep a log. Say your calories needed per day is 3000, now add 500 calories to that which gives you 3500. Write down in a log book everything you ate or drink in a day and add up the calories. One you has stopped gaining weight this way, then simply add another 500 calories and so on until you reach your target weight.You should always drink 1-2 gallons of water per day.

Try to get most of your calories from proteins,healthy fats, carbohydrates,and simple sugars. Your protein source is going to be totally up to you but this is what i use: carnivore beef protein,red meat,burgers,chicken,tuna,eggs,and turkey. Try to eat clean, even when bulking. When people say eat clean it means make home cooked meals basically. Don’t add unneeded salts and butter,spices,or fats. It’s unnecessary and really unhealthy.

Conclusion

Guys, now we have covered all the basic necessities of what’s needed to get big and lean. It’s really easier then you think but here it is again broken down for you.

Training-make sure you keep your body guessing and train with 100% intensity giving yourself a break on two days. Be sure to use basic compound movements when bulking.

Sleep-very important that you get 6-8 hours of sleep.

Gear- The only two drugs needed to remain healthy and get huge is Testosterone and DECA or eq. The drugs are the least important.

Diet- You must eat and I can’t stress this enough, the more food you eat, the bigger you will get. Eating is the most important factor in getting big, IMO.

Food has to be your number one priority and I can guarantee you that if your not growing , it has something to do with one of the above mentioned. Best of luck to you guys and like i said, be patient because that is the reason why most guys do not make it to be HUGE, they didn’t try long enough.

P.S. It took me 14 yrs to look like I do and all I did to get there is do what I just wrote.

Written By: Kane999

Dianabol:Profile

Pharmaceutical Name: Methandrostenolone / methandienone
Chemical structure: 17 beta-hydroxy-17alpha-methyl-1,4-androstadien-3-one
Effective dose: 15-50 mg / day orally or 50-150 mg / week by injection

Methandrostenolone is without a doubt one of the best, if not the best product for people who compete in non-aerobic oriented sports. It promotes drastic protein synthesis, enhances glycogenolysis (repletion of glycogen after exercise) and stimulates strength in a very direct and fast-acting way. It may be less useful to those competing in aerobic events as it also diminishes cell respiration1. But methandrostenolone manifests itself in a distinct manner : rapid and fast-acting build-up of strength and mass is noticed. That’s why its often used at the beginning of cycle consisting of mostly injectables like long-acting testosterone esters and nandrolone. Since the effects of such drugs don’t fully come out for the first 10-15 days, methandrostenolone is dosed in to provide immediate and visible results. It has a rather weak androgenic component and an obviously quite strong and visible anabolic component. Its effects are largely non-AR mediated, which is documented by its rather low influence on the natural endocrine system2 and the fact that it decreases rather than increases red blood cell content in the blood. Which means that one worry users of Dianabol, especially short term, needn’t fear is the dramatic shutdown of natural testosterone production as is often the case with very androgenic compounds. Of course this effect is dose-dependent. It still has a mild androgenic component, meaning in high doses (30+ mg daily) androgen-mediated side-effects can be noted (acne, male pattern hair loss).

Because of its fast effects, immense popularity and the increasing “more-is-better” sentiment among bodybuilders, increasingly high doses are indeed being used and recommended. One has to wonder about the logic of such recommendations however, since high dose urine-analysis showed portions of unmetabolized compounds were being excreted3. In simpler terms that means that with higher doses, higher amounts of unchanged methandrostenolone were being excreted in the urine. This would indicate that the current stance needs to be reviewed and that smaller doses, taken multiple times per day would deliver better results and maximal use of the steroid. Dianabol simply is highly effective in low doses(25-40 mg ed). Som say Anadrol, a comparable steroid to methandrostenolone, is better, but its taken in doses of 50-150 mg. If one was to take methandrostenolone in those doses better gains could be expected. Methandrostenolone is also a lot safer in as opposed to the highly toxic and progestagenic anadrol. If one takes into account that the half-life of methandrostenolone in the body is only 3-6 hours, this theory makes even more sense. So taking your daily dose spread over 3 or 4 doses may elicit a better effect than only 1 or 2 doses. Methandrostenolone is quite effective in these lower doses by the way. Milligram for Milligram its more powerful than a testosterone ester, generally considered the best mass-builder.

A few notes there need to be made however. Not everyone should try and spread their doses out over multiple servings. First of all there is a slightly lower efficacy to take into account here as well due to two characteristics. The first being that you feed the total amount to the liver in smaller portions, yet the liver still manages to metabolize the same amount. Percentage wise that means less methandienone would make it through totally. The second would be that the peak levels aren’t quite as high since no large doses are taken all at once. These two facts make it hard to recommend that just anyone take multiple doses. People who take moderate to low doses of ONLY methandrostenolone should probably opt for a single morning dose. This delivers a higher peak level and more survival of your only steroid. It also, due to the short half-life, makes the drug clear the body before the body produces its largest dose of natural testosterone, the early hours of sleep. Combined with the already mild effect at the AR, you could keep a good amount of your gains when using clomid or Nolvadex post-cycle. For those using it in conjunction with other, mostly injectable steroids, two doses seems to be the better choice, if you are taking in excess of 40 mg a day perhaps even three doses.

This is usually the case for fast-acting substances, they have short half-lives. Which brings us to the point of prolonged use. The general concensus is that methandrostenolone should never be used more than 6 weeks on end due its strong hepatoxic effects. Being largely an oral compound, its also 17-alpha-alkylated to help it survive the liver upon first pass. Liver values are elevated over a short period of time4, making long-term use a very dangerous affair. Liver values should return to normal quite fast after discontinuation however since the effects are so short-lived. Other risks associated with the use of methandrostenolone include the apparition of estrogenic side-effects because it interacts rather well with the aromatase enzyme on account of its methylated properties. It is therefore best used in conjunction with an anti-estrogen. Gynocomastia, high blood pressure, salt and water retention and mild cases of acne are therefore not uncommon.

Its methylated properties (17-methyl group) does have several positive characteristics of course. Why else would they add this group? The main purpose of course it to make sure less of the methandrostenolone is affected by hepatic breakdown when taken orally. But apparently it also decreases the affinity of the drug to SHBG (sex-hormone binding globulin), a sex steroid binding protein that takes up as much as 98% of testosterone. Testosterone that can’t be used to build muscle. Since methandrostenolone does not bind to this protein easily, its quite an active substance, no doubt accounting for its fast and immediately visible action. Dianabol also does not affect cholesterol levels to a high degree in moderate doses5, and it seems to help an athlete stock up on potassium6. This is particularly beneficial taking into account the amount of sodium its estrogenic effects store as well.

We hinted at the short time of activity methandrostenolone possesses. This means that despite its immediate, fast and explosive gains in both strength and mass, they are quite hard to maintain. Often the bulk of mass is lost shortly after discontinuation, making it most unsuitable for those looking to gain and keep quality muscle. An injectable may suppress some of these obviously flawed characteristics, but the 5 mg tabs remain the trend. With its high capacity to survive breakdown in the liver this understandably.

In light of the evidence presented, we conclude that the best use for methandrostenolone is short-term, for 5-6 weeks, at the beginning of a longer bulking stack (10+ weeks), preferably injectable, to kickstart gains and strength. Its effects are largely non-AR mediated and it aromatizes quite well, which leaves it with limited stacking partners, The best candidates are of course nandrolone and testosterone. It should be taken in doses no higher than 50 mg (20-40 mg being the norm) ,spread over multiple doses for maximum effects in stacks and a single morning dose when taken by itself. D-bol remains a favorite today however, that’s a fact that cannot be argued.

I needn’t really expand too much, since most of the conclusion were drawn in that last paragraph. Dianabol is a methylated compound with a certain toxicity, so in the interest of safety you wouldn’t use it longer than 6 weeks on end, 8 weeks at the absolute maximum and only under supervision of a medical professional who can monitor your liver values. Because it heavily aromatizes its not particularly useful during cutting and with 6-8 weeks of use maximum, that leaves but two options. Either stacking it with another, injectable, compound that can be used for longer terms (beginning of stack when other compound is least active) or you would do multiple short cycles. In that case one would take off at least as long as he was on during a cycle, preferably longer. Like 6 weeks on, followed by 6-10 weeks off. These multiple cycles were all the fashion among pro bodybuilders in the 70′s with very decent results.

It’s most readily stacked with Deca-Durabolin or Primobolan, perhaps even Equipoise. Usually an injection of 200-400 mg/week combined with 30-40 mg of Dianabol everyday. In some cases testosterone was used in conjunction with anyone of these stacks. For short term use oral Primobolan made a good match, and in lesser ways an oral Winstrol. Both provide a mild, lean foundation for the Dianabol and both are also 17-alpha alkylated, warranting short-term use. Since Dianabol has little Androgen receptor activity, it functions particularly synergistic with compounds that have a strong Androgen receptor activity as is the case for all the aforementioned. Along the lines of secondary products an anti-aromatase like Cytadren or Arimidex may be useful. When stacked with Deca, the choice for a receptor antagonist like Clomid or Nolvadex is perhaps a wiser choice. Perhaps even a combination of both. Dianabol aromatizes rather heavily, which means in a stack with another aromatizing compound the risk for gyno remains high and water retention is virtually a fact. Post-cycle the use of Clomid or Nolvadex can be employed to boost natural testosterone production. There is quite some circulating estrogen post-cycle that causes prolonged negative feedback, clomid or Nolvadex would solve that problem and help you retain more of your gains.

Sustanon 250: Profile

Pharmaceutical Name: Testosterone (as 30 mg propionate, 60 mg isocaproate, 60 mg as phenylpropionate, 100 mg decanoate)
Chemical structure: 4-androstene-3-one,17beta-ol
Effective dose: 250-1000 mg/week

Testosterone is the prime male androgen in the body, and as such still the best possible mass builder in the world. It has a high risk of side-effects because it readily converts to a more androgenic form (DHT) in androgen responsive tissues and forms estrogen quite easily. But these characteristics also provide it with its extreme anabolic tendencies. On the one hand estrogen increases growth hormone output, glucose utilization, improves immunity and upgrades the androgen receptor, while on the other hand a testosterone/DHT combination is extremely potent at activating the androgen receptor and eliciting major strength and size gains. While not always the most visually appealing result, there is no steroid on earth that packs on mass like testosterone does.

Sustanon 250 is a unique blend of 4 different esters of testosterone. The principle purpose of attaching an ester to a steroid is to make it more lipophillic, so that when injected intra-muscularly it can remain in the adipose tissue longer and is released in the blood-stream over time. The longer an ester, the more lipophillic it is. Sustanon 250 contain 1 short, 1 long and 2 medium length esters that are all delivered over time, which gives a quick release, but a durable one as well. You may think that this is a positive thing, and to patients requiring testosterone therapy this probably is, but to a steroid user its really not.

A steroid user will use a long-acting testosterone and inject it once a week. The end of a week is usually the time when a long-acting (7 or 8 carbon) ester has tapered down to its original level and threatens to drop below that level, giving sub-par amounts of testosterone beyond that point (eventhough the compound stays somewhat active for 3-4 weeks). With sustanon, that equal amount is divided much differently. Imagine a hypothetical situation where one take either 270 mg of a an ester that lasts 6 days, or 270 mg of a blend of different esters, 90 mg each, that release over respectively 2, 4 and 6 days, analog to sustanon. With the first one, an even amount of testosterone is released on each day. With the second one the entire first ester, half the second ester and 1/3rd of the last ester is released within the first two days. The result here is clear : the first two days one gets 165 mg, the next two one gets 75 mg and the last 2 days one gets a mere 30 mg. The levels peak much sooner, and drop off sooner, leaving you with less than adequate androgen levels as the week draws to a close.

So for use as one would use another long-acting testosterone, I find sustanon to be poor value. The price is roughly the same so I really don’t see the affinity people seem to have for it. Respectively cypionate and enanthate are much better choices. I can understand the need for a fast-acting component to front-load and kick-start gains, but even then, testoviron (200 mg testosterone enanthate and 50 mg testosterone propionate) is a much better choice. Speaking of front-loading, for this express purpose sustanon may be very suited. One could probably obtain results faster If one were to use 500 mg of sustanon on day 1, then again 5 days later on day 6 and start a cycle of enanthate/cypionate at 500 mg/week on day 11. That avoids the major crash at the end of the week and makes maximum use of the fast acting esters to saturate the system.

As with all testosterones the rate of side-effects is quite high. Risks of androgenic side-effects (hair loss, prostate hypertrophy, deepening of voice) as well as estrogenic side-effects (gyno, water retention, fat gain) are real, and the use of ancillary drugs such as anti-estrogens will most likely be needed. This is something that I urge all users to take into account. Never start any cycle with testosterone without having at least a lot of Nolvadex and a few amps of HCG on hand. Testosterone is not in any way toxic, and should not give a user any problems apart from a high rate of occurrence of standard steroid side-effects.

Because of its long-acting components, sustanon is mostly used as a form of long-acting testosterone. Much like testoviron, testosterone enanthate and testosterone cypionate. I don’t find it to be the best choice for this purpose, but obviously I don’t determine the trends among bodybuilders. In such use doses of 500 to 1000 mg per week are used in a single injection, with decent results nonetheless. Perhaps because 3 of its esters are notably shorter than enanthate or cypionate, so more of it is actual testosterone and less ester, eventhough the distribution is uneven. Its best use in my opinion is to start off a cycle with, by injecting twice with 5 days space, and then give it another 5 days before starting an 8-10 week cycle of testoviron, enanthate or cypionate. This should allow for more testosterone to build up and results to come much faster.

Again, because of the two medium-length and the long ester, the compound is not very controllable. So when problems occur, simply discontinuing the product is not an option. One needs to be familiar with anti-estrogenic compounds for one. When signs of gyno appear using 20-40 mg/day of the estrogen antagonist Nolvadex or 100-150 mg/day of its weaker counterpart clomid until a few days after symptoms disappear is advised. The best way to avoid such problems is running proviron or arimidex, aromatase blockers, alongside the product. In most instances I give preference to arimidex, but when concerning the use of testosterone Proviron at 50-100 mg per day may be wiser since it frees up more testosterone.

Of course the simultaneous use of an aromatase blocker will compromise your gains since it literally stops estrogen from being made. Androgenic problems can be reduced to some extent by the use of finasteride, which will stop the conversion of testosterone to its more androgenic component DHT. This may alleviate aggravated hair loss and prostate problems somewhat. Again, the blocking of such a conversion may decrease the gains made and will in any case heighten the risk for estrogenic side-effects, since DHT acts as an anti-estrogen. Proviron is also a form of DHT, so people worried about androgenic side-effects should then naturally opt for arimidex over proviron when they choose an aromatase blocker as well. Sustanon stacks well with any compound. Usually testosterone is always the stronger compound in the stack, so whenever you stack something alongside its usually because the drug has certain characteristics. Usually this means it will be a milder drug that will allow the user a milder cycle with lower occurrence of side-effects than simply using more testosterone, without having to give up all of the potential gains. Deca-Durabolin, Equipoise and Primobolan are some of the more fitting compounds for this purpose. But naturally the king of all mass-builders stacks well with almost anything.

Basic Insulin Guide For Beginner’s

If you are a seasoned insulin user, this post is going to be WAY too basic to be of value to you. The purpose of this post is to answer the very basic questions for those completely unfamiliar with insulin and its use in the body and for bodybuilding purposes.

There are a lot of post about insulin and how it is used for bodybuilding purposes. But more basic than this, I am frequently asked….what exactly is insulin and what is it really doing for my body. Here is just a REALLY basic overview of what insulin is in the most basic of terms.

What is Insulin for?
Your body’s main source of fuel is a form of sugar called glucose. It gives us energy. After we eat, glucose enters the bloodstream and signals a gland near the stomach, the pancreas, to make insulin.

Insulin is a chemical that helps cells in your body use glucose. Insulin is the storage hormone, glucose disposal chemical, and the main shuttle of glucose into our muscles and other cells. As cells use glucose for energy, the level of glucose in the bloodstream drops. If there is no insulin or the insulin isn’t doing its job too much glucose builds up in the bloodstream. This is the condition (hyperglycemia) you find when you have diabetes.

Basic Types of Insulin
There are many different types of prescription insulin. Some are designed to work right away and don’t last very long. Other types act more slowly over longer periods of time. Doctors routinely prescribe the type of insulin that matches your body’s needs for diabetics. Each case of diabetes is slightly different, and depending on the length of time and severity of the condition, the individual need for insulin and its active window varies greatly. This is why you see so many different brands and types on the market. Depending on the symptoms and condition of the diabetic, the insulin type is tailored to their needs.

Bodybuilding use of Insulin
Now let’s cut forward to all of us that are NOT diabetic. Our reason for using insulin is to use its inherent shuttling ability to shuttle nutrients to the muscles. For our purpose we are not trying to achieve long term control of glucose buildup in the bloodstream. We are trying to transport supraphysiological amounts of protein and sugars to the muscles for fuel, repair, and growth. For our purposes, we want to use a quick acting, short lasting insulin. Longer lasting insulin will most likely just equate to added fat … and not provide any additional positive function. We are using this ONLY as a nutrient shuttle … which is only needed after we have worked out our muscles and torn them down …. this is when they are screaming out for glycogen and protein.

As we learned above, insulin’s purpose is to pull glucose out of the bloodstream and ship it out … helping cells use it. The problem with this is the brain has a really, really small limited range of blood sugar levels that it will function within. If we put too much sugar into our system uncontrolled by insulin, we check out for good. If we have too much insulin and our blood sugar drops too low, same result….we check out. This is the danger that is inherent in manipulating insulin for our bodybuilding purposes. This is also why the timing of carbs immediately after insulin injections is critical.

What, When, and How?
For the purpose of bodybuilding, we want to use a short acting insulin (such as Humalog, or if not available next best Humulin-R). Either of these should be very inexpensive to purchase (under $40). The dose required will end up being between 4-10 IU’s, and even in the most advanced users under 15 IU’s should get the job done. For beginners, stay in the 8-10 IU range. The most advantageous time to use this is immediately post workout, when our muscles are screaming out for nutrients and are in a catabolic state. We use a U-100 insulin syringe with 1/2″ needle to inject IM immediately post workout. Alternatively, you can inject sub-q if desired. When starting out using insulin, begin with a dose of 2IU’s or so, and increase the dose each workout day until you reach your desired maximum.

Immediately following your injection, you will want to do the following religiously:
injection + 5 minutes ? drink shake with 10g glutamine / 10g creatine / 55g dextrose (based on 7-8 IU’s – 7-8 grams per IU more precisely)
Injection + 15 minutes ? drink shake with 80g of whey protein in water
Injection + 60 ? 75 minutes ? eat a protein / carb meal with 40-50g of protein, 40-50g of carbs, NO FATS
Avoid fats for 2-3 hours for Humalog IM, 3-4 hours for Humalog sub-q, 4-5 hours for Humulin-R.

Things to Watch for
Insulin’s most commons side effect is HYPOGLYCEMIA (low blood glucose). It is important that you know the signs of hypoglycemia they may occur quickly!
They are:
- Shakiness
- Anxiety
- Fast heart beat
- Hunger
- Sweating
- Blurred vision
- Dizziness
- Weakness
- Headache
- Irritability

If any of these symptoms occur, you should eat some form of quick acting sugar to prevent the symptoms from getting worse (e.g., two or three glucose tablets, one tube of glucose gel, one-half cup of fruit juice or regular soft drink, one tablespoon of honey, or one tablespoon of sugar dissolved in water)

Always have something like the above on hand when using insulin. Hypo symptoms can and will hit hard and fast, and you will have a very small window of time to react. Be ready!!

Well, hopefully you now have a basic understanding of insulin. There are many other in-depth articles and studies available that I would encourage you to read and study, especially before venturing into insulin use. While it is extremely useful for bodybuilding, it is also dangerous enough to not be taken lightly…..know what you are doing and have a plan BEFORE you begin to consider using insulin. As in anything we do, research, research, research!!! Hopefully this post will whet your appetite to look into insulin…..used properly it is definitely one of modern bodybuilding’s great tools.

Igf-lr-3 Basic Guide

What is it? And why is the difference between huIGF-1 and LR3 IGF-1?

IGF-1 stands for insulin like growth factor. IGF-I is the primary protein involved in responses of cells to growth hormone (GH): that is, IGF-1 is produced in response to GH and then induces cellular activities. One such example is muscle growth or hyperplasia
This compound also makes the human body more sensitive to insulin. It is the most potent growth factor found in the human body. IGF-1 causes muscle cell hyperplasia, which is an actual splitting and forming of new muscle cells, this is a good thing.

LR3 IGF-1
Long Recumbent 3 IGF-1, which is an 83 amino acid analog of human IGF-1 sequence with the substitution of an arg for the glu at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus (hence the long).

HuIGF-1
It has a 70 amino acid string. It is very short lived in the body (half life of probably around 10-15 minutes). This type of IGF-1 is very useful if you are seeking local site growth. Since it is so short lived, little of the IGF-1 makes it to other tissues and IGF-1 receptors in the body. The way to inject this is immediately post work out into the muscle that you wish to have local site growth.

This coupled with PGF2a and TNE would do wonders for site specific growth IMO.

Usage
It needs to be shot PWO. Most shoot bilaterally into the muscle that was worked.

Stacking- because LR3 increases hyperplasia it is best when used in conjunction of other AAS.
The ideal situation would be to inject twice ED due to the life of LR3. If this isnt feasible PWO will suffice, and suffice well.
If you are on your off day, in the AM is best. It will help fight catabolism.
If you add insulin to your LR3, be careful. LR3 will make you more sensitive to the effects that insulin has on you. So raise your PWO carb intake to accommodate the added LR3.

If you have never ran insulin before, DO NOT add it with LR3.

What can I expect?
First off you can expect to drop a little BF if your diet is good. LR3 seems to burn off fat.
You can expect an increase in hunger, this is awesome when bulking. That though can be controlled while cutting.
Another thing to remember is hyperplaisa, once again the forming of new muscle cells, thus more size. Strength will go up along with the new muscle mass.
You can expect great pumps. For some people so bad it hurts… you be the judge. I for one have never got pumps that hurt like that… for me personally I feel more pumps with insulin.

Dosing For LR3
The general consensus for dosing LR3 seems to be 40mcg to 60mcg. For no longer than 5 weeks. Do not exceed 100mcg. The average user should have no reason to ever come close to that dose. Some people shoot everyday, some just PWO. So on the days you do not work out the best thing to do is shoot whenever you wake up this helps maintain constant blood levels and helps fight of catabolism.

The first time user should just use 40mcg on PWO days only. This way you can use 40mcg for 5 weeks assuming you have just one MG of LR3. It is a great starting dose that will get you results. But if you have used 40mcg in the past and didnt see the results you wanted, try 60mcg.

A great way to run a cycle that includes IGF would be this-
weeks 1-12 test enanthate E3D 500-750mg a week
Weeks 1-4, 15-19* 40mcg of LR3 ED
PCT 14-18

*I do not feel that its needed the first week of PCT, if my weight falls off it does in weeks 2-3, so I want to aleviate that problem.

Dosing For huIGF

This is about the same as LR3, this is stritcly my opinion based on what I have gatherd and read. As there is next to no information on this. So from what I know about it, this is how Id/do/will use it.
PWO with 30-40mcg into each muscle that was worked. 20-30 min later, repeat. Do this for 4 times. for a total of 120-160mcg
And if I were using this Id use it with humalog. The insulin will remain active for over and hour after the IGF was injected. So this will get all the possible gains from it that you could.

How to figure out dosing

Ok I get, I should use 40mcg…. but how do I figure that out?

1mg = 1000mcg… assuming there is 1ml of liquid we can say that 1ml = 1000mcg and also = 100units…
So 2 units = 20 mcg
The best way to measure this is to use an insulin syringe. You can get away with a 1cc syringe but I prefer to use the .5cc or even the .33cc ones. They measure out each unit, so when you are measuring two units it is much easier on the smaller pin. While the 1cc syringe is fine, it is mesured out by two IU at a time. So one “tick” on the 1cc is 2iu, the .5cc each “tick” is one IU.

Wow so you mean you?re telling me I shoot 4iu of this stuff? What if I do not get it all out of there ?

I thought you would never ask. I have found the best way to get it and even measure my LR3 is like this. First draw out 30iu of B12 or BW (bacteriostatic water) on the dot. Then draw your LR3 out for a total of 34iu. This means you have 4iu of LR3 in the end of your syringe. Shoot out all of it and that way you can be sure all of the LR3 is out and into your desired muscle of choice.

Reconstitution
RedBaron has a great thread on reconstitution with AA (acetic acid), check it out here.
But just about always you do not have to worry about reconstituting it yourself. All of the manufacturers usually suspend their LR3 in either BA or AA for you.

Storage

The stability of a liquid solution of LR3IGF-I was monitored for a period of two years at storage conditions of -20 C, +4 C, +22 C, and +37 C. The final concentration of LR3IGF-I was in acetic acid. At various time points, samples were taken and compared to a lyophilized control (stored at 4 C). Listed below are the stability results for each respective storage condition.

Storage Condition: -20 C (-4 F)
Biological Potency No Change up to 2 years
Immunological Activity No Change up to 2 years
Mobility of Protein No Change up to 2 years
Elution Profile by reversed phased HPLC No Change up to 2 years

Storage Condition: +4 C (39.2 F)
Biological Potency No Change up to 2 years
Immunological Activity No Change up to 2 years
Mobility of Protein No Change up to 2 years
Elution Profile by reversed phased HPLC No Change up to 2 years

Storage Condition: +22 C (71.6 F)
Biological Potency No Change up to 2 years
Immunological Activity No Change up to 2 years
Mobility of Protein No Change up to 2 years
Elution Profile by reversed phased HPLC No Change up to 2 years

Storage Condition: +37 C (98.6 F)
Biological Potency No Change up to 1 year
Immunological Activity No Change up to 1 year
Mobility of Protein No Change up to 1 year
Elution Profile by reversed phased HPLC No Change up to 1 year

In conclusion
There is no significant difference in the potency of LR3IGF-I associated with the storage of the liquid formulation when stored at this range of temperatures. There is no evidence for loss of biological activity at any of the tested temperatures when stored as a liquid product. As you can see IGF can be quite stable for even a year at room temp, but if you want to keep it around for a while stick it into the fridge. So IMO the best way to store LR3 that is suspended in BA is in the freezer. The BA wont allow it to freeze. And if you have it suspended in AA, store it in the fridge.

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