Posts Tagged ‘Steroids’

Sustanon 250: Profile

Pharmaceutical Name: Testosterone (as 30 mg propionate, 60 mg isocaproate, 60 mg as phenylpropionate, 100 mg decanoate)
Chemical structure: 4-androstene-3-one,17beta-ol
Effective dose: 250-1000 mg/week

Testosterone is the prime male androgen in the body, and as such still the best possible mass builder in the world. It has a high risk of side-effects because it readily converts to a more androgenic form (DHT) in androgen responsive tissues and forms estrogen quite easily. But these characteristics also provide it with its extreme anabolic tendencies. On the one hand estrogen increases growth hormone output, glucose utilization, improves immunity and upgrades the androgen receptor, while on the other hand a testosterone/DHT combination is extremely potent at activating the androgen receptor and eliciting major strength and size gains. While not always the most visually appealing result, there is no steroid on earth that packs on mass like testosterone does.

Sustanon 250 is a unique blend of 4 different esters of testosterone. The principle purpose of attaching an ester to a steroid is to make it more lipophillic, so that when injected intra-muscularly it can remain in the adipose tissue longer and is released in the blood-stream over time. The longer an ester, the more lipophillic it is. Sustanon 250 contain 1 short, 1 long and 2 medium length esters that are all delivered over time, which gives a quick release, but a durable one as well. You may think that this is a positive thing, and to patients requiring testosterone therapy this probably is, but to a steroid user its really not.

A steroid user will use a long-acting testosterone and inject it once a week. The end of a week is usually the time when a long-acting (7 or 8 carbon) ester has tapered down to its original level and threatens to drop below that level, giving sub-par amounts of testosterone beyond that point (eventhough the compound stays somewhat active for 3-4 weeks). With sustanon, that equal amount is divided much differently. Imagine a hypothetical situation where one take either 270 mg of a an ester that lasts 6 days, or 270 mg of a blend of different esters, 90 mg each, that release over respectively 2, 4 and 6 days, analog to sustanon. With the first one, an even amount of testosterone is released on each day. With the second one the entire first ester, half the second ester and 1/3rd of the last ester is released within the first two days. The result here is clear : the first two days one gets 165 mg, the next two one gets 75 mg and the last 2 days one gets a mere 30 mg. The levels peak much sooner, and drop off sooner, leaving you with less than adequate androgen levels as the week draws to a close.

So for use as one would use another long-acting testosterone, I find sustanon to be poor value. The price is roughly the same so I really don’t see the affinity people seem to have for it. Respectively cypionate and enanthate are much better choices. I can understand the need for a fast-acting component to front-load and kick-start gains, but even then, testoviron (200 mg testosterone enanthate and 50 mg testosterone propionate) is a much better choice. Speaking of front-loading, for this express purpose sustanon may be very suited. One could probably obtain results faster If one were to use 500 mg of sustanon on day 1, then again 5 days later on day 6 and start a cycle of enanthate/cypionate at 500 mg/week on day 11. That avoids the major crash at the end of the week and makes maximum use of the fast acting esters to saturate the system.

As with all testosterones the rate of side-effects is quite high. Risks of androgenic side-effects (hair loss, prostate hypertrophy, deepening of voice) as well as estrogenic side-effects (gyno, water retention, fat gain) are real, and the use of ancillary drugs such as anti-estrogens will most likely be needed. This is something that I urge all users to take into account. Never start any cycle with testosterone without having at least a lot of Nolvadex and a few amps of HCG on hand. Testosterone is not in any way toxic, and should not give a user any problems apart from a high rate of occurrence of standard steroid side-effects.

Because of its long-acting components, sustanon is mostly used as a form of long-acting testosterone. Much like testoviron, testosterone enanthate and testosterone cypionate. I don’t find it to be the best choice for this purpose, but obviously I don’t determine the trends among bodybuilders. In such use doses of 500 to 1000 mg per week are used in a single injection, with decent results nonetheless. Perhaps because 3 of its esters are notably shorter than enanthate or cypionate, so more of it is actual testosterone and less ester, eventhough the distribution is uneven. Its best use in my opinion is to start off a cycle with, by injecting twice with 5 days space, and then give it another 5 days before starting an 8-10 week cycle of testoviron, enanthate or cypionate. This should allow for more testosterone to build up and results to come much faster.

Again, because of the two medium-length and the long ester, the compound is not very controllable. So when problems occur, simply discontinuing the product is not an option. One needs to be familiar with anti-estrogenic compounds for one. When signs of gyno appear using 20-40 mg/day of the estrogen antagonist Nolvadex or 100-150 mg/day of its weaker counterpart clomid until a few days after symptoms disappear is advised. The best way to avoid such problems is running proviron or arimidex, aromatase blockers, alongside the product. In most instances I give preference to arimidex, but when concerning the use of testosterone Proviron at 50-100 mg per day may be wiser since it frees up more testosterone.

Of course the simultaneous use of an aromatase blocker will compromise your gains since it literally stops estrogen from being made. Androgenic problems can be reduced to some extent by the use of finasteride, which will stop the conversion of testosterone to its more androgenic component DHT. This may alleviate aggravated hair loss and prostate problems somewhat. Again, the blocking of such a conversion may decrease the gains made and will in any case heighten the risk for estrogenic side-effects, since DHT acts as an anti-estrogen. Proviron is also a form of DHT, so people worried about androgenic side-effects should then naturally opt for arimidex over proviron when they choose an aromatase blocker as well. Sustanon stacks well with any compound. Usually testosterone is always the stronger compound in the stack, so whenever you stack something alongside its usually because the drug has certain characteristics. Usually this means it will be a milder drug that will allow the user a milder cycle with lower occurrence of side-effects than simply using more testosterone, without having to give up all of the potential gains. Deca-Durabolin, Equipoise and Primobolan are some of the more fitting compounds for this purpose. But naturally the king of all mass-builders stacks well with almost anything.

Halflife Of Steroids

An important consideration when planning a steroid cycle, in particular the timing of dosing to be administered, is the active half-life of the drug being employed. The half-life may be defined as the time (t) the level is half of the starting level of a given compound; at time 2t, the level is a quarter of the starting level, and at time 3t, the level is an eighth of the starting level, and so on.

This information is vital in the timing of the dosing when attempting to achieve a more stable blood concentration, which leads to greater overall results and maintenance of gains. Some fluctuations of concentration levels are acceptable, and are also mostly unavoidable, but should be kept to a minimum.

This article covers the half-life’s of the most commonly used steroids, esters and ancillary compounds.

Oral steroids Drug Active half-life
Anadrol / Anapolan50 (oxymetholone) 8 to 9 hours
Anavar (oxandrolone) 9 hours
Dianabol (methandrostenolone, methandienone) 4.5 to 6 hours
Methyltestosterone 4 days
Winstrol (stanozolol)
(tablets or depot taken orally) 9 hours

Depot steroids Drug Active half-life
Deca-durabolin (Nandrolone decanate) 15 days
Equipoise 14 days
Finaject (trenbolone acetate) 3 days
Primobolan (methenolone enanthate) 10.5 days
Sustanon or Omnadren 15 to 18 days
Testosterone Cypionate 12 days
Testosterone Enanthate 10.5 days
Testosterone Propionate 4.5 days
Testosterone Suspension 1 day
* Winstrol (stanozolol) 1 day

*Winstrol depot does not actually possess a classical half-life because it is un-esterified. Instead, the microcrystals dissolve slowly. Once they have all dissolved levels of the drug fall very rapidly. It is still an important consideration, and we have included it with a half-life of one day.

Steroid esters Drug Active half-life
Formate 1.5 days
Acetate 3 days
Propionate 4.5 days
Phenylpropionate 4.5 days
Butyrate 6 days
Valerate 7.5 days
Hexanoate 9 days
Caproate 9 days
Isocaproate 9 days
Heptanoate 10.5 days
Enanthate 10.5 days
Octanoate 12 days
Cypionate 12 days
Nonanoate 13.5 days
Decanoate 15 days
Undecanoate 16.5 days

Ancillaries Drug Active half-life
Arimidex 3 days
Clenbuterol 1.5 days
Clomid 5 days
Cytadren 6 hours
Ephedrine 6 hours
T3 10 hours

A practical example is if one was to inject 100mg of testosterone propionate and allow blood levels to peak. In 4.5 days time (half-life duration from the above tables) and providing no other injections had taken place, the level would be reduced to 50mg. Again, a further 4.5 days down the line and levels would have dropped to 25mg, and the value keeps halving every 4.5 days.

Basic Steroid Cycles

A lot of people don’t know where to start with their first cycle or where to go from there after their first cycle. This is kind of a guide to how to do it right and how to schedule your progression.

First Cycle:
Test E 500mg per week x 10 weeks

This is the cycle that a beginner should use to test the waters so to speak. You can expect great gains from this. Make sure that you have PLENTY of nolvadex on hand to combat any gyno issues and for post cycle therapy.

Second Cycle:
Test E 500mg per week x 10 weeks
Deca 400mg per week x 10 weeks

This is a great cycle! You already know how your body responds to test, so it is easier to gauge what type of progress your body makes with deca. You should never add more than one unfamiliar compound to any cycle. It makes it too difficult to figure out which compound is doing what to your body.

Third Cycle:
Test E 500mg per week x 10 weeks
Deca 400mg per week x 10 weeks
Dbol 30mg per day x weeks 1-4

This will be the first cycle in which you introduce an oral steroid. This will give you a great boost in mass and strength and let you become familiar with another compound.

After you have completed these three cycles you are probably ready to start increasing dosages slightly (if necessary). Remember that it is healthy and monetarily sound to use as little of a compound as it takes to get the result that you desire.

After you get done with these three basic beginner cycles you should know enough about how you respond to steroids to design your own cycles.

***antiestrogens and pct weren’t really discussed much in this thread, but know that they are necessary and you should research them THOROUGHLY before starting any cycle.***

The Inside Look At Winstrol-V

I tend to shy away from straight “information” articles- in other words, I’ve never written the “How Androgens Work” article, because I’ve read it several times by several authors, and I really have nothing to add. Gene Transcription and Androgen Receptor Action has been written about over, and over, ad nauseum. All of the articles I’ve read on the topic are well written and well- they’re all the same. Don’t get me wrong, all of the articles which discuss the topic are very informative, but when you’re done reading them, you don’t really have anything you can “use” in your next cycle.

And I’m sure you know the difference between orals and injectables, but do yourself a favor and read this article, because I’m going to explain some things in here that you can use in your next cycle. Actually, I’m going to explain how you can use Winstrol (Stanozolol) as either an oral or injectable, and get a very different set of effects from the same drug- depending on which route of administration you choose to utilize.

First, lets go over the basics of Winstrol, so we’re all on the same page here.

Winstrol is a steroid derived from the base structure of Dihydrotestosterone (DHT). DHT is just testosterone which has been 5alpha-reduced, meaning it has had the c4-5 double bond removed by two hydrogen atoms. This is very interesting from a chemical/biological standpoint. Once this bond is removed, testosterone has become DHT, and DHT is the body’s most potent androgen. DHT has a slew of beneficial effects which are more pronounced than the hormone it’s created out of. DHT is able to increase androgen receptor proliferation for almost 24 full hours (1) DHT also has profound effects on the Central Nervous System (CNS), and this is why we often see profoundly increased aggression with athletes who are using DHT derivatives such as Masteron (which has a deceivingly low anabolic and androgenic rating). As an added benefit, DHT can not aromatize (convert via the aromatase enzyme) into estrogen. It’s also noteworthy that the injectable version of Winstrol is actually the same exact thing as the oral- it’s just micronized Stanozolol  powder suspended in water (or sometimes oil).

So what we have in Winstrol is DHT with two modifications- an added c17 methylation, and a very weird “pyrazol” group. The c17 methylation has been added in order to allow Winstrol to survive oral ingestion and the subsequent first pass through the liver. The pyrazol group is a bit weirder- what this means to you and I is that it has another whole “ring” attached to the four ring Steran Nucleus of DHT. Take a look over at the lower left portion of the two molecules below, and you’ll notice that Winstrol has an added cyclopentane (5 sided) group (the pyrazol group):

DHT Winstrol

When we really take a look at Winstrol, the anabolic rating of this product is very high (320% that of testosterone) as compared to its androgenic actions (30% of testosterone). Despite this, Winstrol is really a disappointing drug for size gains. What we typically see with this stuff is some pretty decent strength gains and some nice fat loss if the user isn’t too sloppy with their diet. Not many people report huge weight gains off of Stanozolol. Although many drugs which bind tightly to the androgen receptor are suspected to exhibit their at least some of their lipolytic (fat-burning) effects through receptor binding affinity.  The effects of androgens on the regulation of lipolysis in adipose precursor cells.(2), Winstrol remains a potent cutting drug, despite the fact that it has a relatively weak AR binding ability (3). What this tells me is that there’s some stuff going on with regards to Winstrol’s mechanism of action, which doesn’t involve androgen receptor mediated effects. Still, Winstrol is a very potent compound for enhancing protein synthesis (4-5 ) .

As previously discussed, it’s derived from DHT, and DHT is known to have ant-estrogenic effects (6) and Winstrol itself also has anti-progestenic properties (in at least some cases, where it may “block” that receptor) (7). So I think it’s safe to say that some of the “hard” look you can get in your physique from Winstrol is because of it’s ability to inhibit estrogen and progesterone- known culprits in making a physique appear smooth. Unfortunately, since it is 17aa, it is also liver toxic, especially more so when you inject it and it is subject to what is known as the “first pass” through the liver. The difference between taking oral vs. injectable Winstrol, even though it’s technically the same drug, is how and when your body metabolizes it. When you consume a drug orally, that drug is absorbed from the Gastrointestinal tract, where it then passes via the portal vein into the liver -where some drugs are metabolised. This “first pass” can mean that only a certain portion of the drug reaches your body’s bloodstream. As previously discussed, a 17aa has been attached to Winstrol to allow a sizeable portion to survive this metabolism.

First pass metabolism can occur in both the gut and the liver, and where this happens can vary with different drugs. First pass metabolism actually occurs in your gut for some drugs and in the liver for others. Once it has been metabolized, it enters the bloodstream. It’s important to note that when a blood is metabolized in the Gastrointestinal tract, the blood leaving the Gastrointestinal tract does not go right to the heart, but actually still passes through liver via the hepatic portal vein and then ultimately returns to circulation via the hepatic vein. The liver is your body’s filtration unit, and removes large quantities of nutrients, dangerous toxins (or fun toxins, depending on what they are) and other substances from the blood.

So as you can see, when you take an oral steroid such as Winstrol, undergoes a first-pass metabolism in the both the intestines as well as liver. Some drugs can be absorbed more or less totally intact, after only moderate metabolic activity, while some are absorbed only after very extensive metabolic activity. Once it is through this first pass, a given drug then circulates in the blood until it is acquired by another tissue, such as skeletal muscle. Now, if the drug reaches the liver again, it may undergo what is cleverly known as “second-pass” metabolism. Of course, in the case of Winstrol, an injectable version is available, and when we compare the oral and injectable versions of Winstrol and their effects in your body, I think there’s some surprising differences. The injectable is (naturally) put right into your bloodstream and only undergoes the far less extensive second pass metabolism, while the oral must endure the gut and liver on it’s first pass before ending up in circulation.

Now, here’s the interesting part: When you inject Winstrol, instead of taking it orally, you actually get more nitrogen retention (4) (and hence we can infer, more new muscle tissue is being built). SO if you are trying to use Winstrol to build new muscle tissue, the injectable version is going to be far superior to the Oral version. However, there are some advantages that the oral version has over the injectable, including a possible “synergy” with other drugs- but only (primarily) when taken orally.

While in the liver, on it’s first pass, Winstrol is exposed to a variety of enzymes and proteins. To understand how a possible synergy between Winstrol and other steroids may be possible, a little background on Sex Hormone Binding Globulin (SHBG) is first necessary. For our purposes here, all we need to know is that SHBG is a glycoprotein produced in the liver, which binds to testosterone and makes it biologically unavailable to do all the things we want it to do- like building muscle. It serves to transport testosterone throughout the body, but while it remains bound to testosterone, the testosterone can not exert it’s anabolic effects.

As you can surmise, a very large portion of the testosterone in your body is bound to SHBG. Wouldn’t it be great if we could lower SHBG? With Winstrol we can.

A fairly conservative oral dose of .2mg/kg of Winstrol has been shown to lower SHBG by close to 50%. (8)For me (200lbs) this would mean I would only need around 18mgs/day to free up half of my SHBG bound testosterone! For my omnipresent and hypothetical “100kg bodybuilder”- only 20mgs would be needed (he’s 220 lbs for the metrically impaired among us). Now, with less SHBG floating around in me, my anabolic steroid cycle will be more effective, right? Right.

But why can we only expect such a dramatic lowering of SHBG with the oral? Well, obviously, we’re taking advantage of the first pass through the liver, where we can have our Winstrol interact with SHBG where it’s produced- in the liver…without going through the bloodstream first.

When we take a look at a study done comparing injectable vs. oral contraceptives, we find that the oral version at 70mgs/week (10mgs/day given orally) is more effective at affecting SHBG levels than 400mgs/week given via an injection! (9)In this study, testosterone undecanoate was given at a constant dose along with norestisterone (which raises SHBG). What we see is that when norestisterone is given orally, it produces a far greater effect on SHBG, than when it is administered via an injection. And this is even when the doses of the injectable are 4x higher!

Here’s a chart, illustrating exactly what I’m talking about in this study, which I think suggests very strongly that injectable versions of drugs, when compared with the oral version, will have nowhere near as much of an effect on SHBG:

Of course, in this study, they’re looking at oral vs. injectable versions of a SHBG raising drug- but what we can take away from it is that SHBG interaction with oral compounds is far more pronounced than it is with injectables.

So lets take a small amount of Winstrol with our cycles, and free up some of those steroids we’re taking, right? Right!

Unless of course, we’re talking about women here…I was recently asked why I recommend that women use the injectable version of Winstrol over the oral. I was asked this question by someone, who I assumed had a female friend who was considering using Winstrol. I then realized I was totally incorrect- not about Winstrol, but about the reason behind the question. You see…I saw a picture of the man who had first asked me the question, and it’s readily apparent to me that he probably doesn’t actually know any women. But still, his question is valid and bears repeating and answering here.

I recommend that women avoid the oral version of this product for the same reason that men will find that it gives them an increased synergy and effectiveness in their cycles.

When SHBG is lowered in women, there is more free testosterone floating around. And as we’ve seen, the oral is going to affect SHBG exponentially more than the injectable will. When we lower SHBG too much in women, we see a strong positive correlation with hyperandrogenism (10 ), and hirsuitism (abnormal growth of body hair), as well In fact, non-SHBG-bound testosterone may actually be the defining characteristic for identifying hyperandrogenism in women. In addition, low SHBG contributes to menstrual irregularity.(11)

Finally, and (partially) anecdotally, we also see a greater incidence of clitoral enlargement and acne when the oral version of Winstrol is used by women instead of the injectable. The reasons for this are obvious- When we increase free testosterone by lowering SHBG, we increase the amount of testosterone which is able to be 5a-reduced to DHT. DHT is the primary culprit for steroid induced acne, and is also the hormone responsible for external genital enlargement. Clearly, this is why we see the increased level of clitoral hypertrophy as well as acne when oral Winstrol is used by women.

We can also see increased acne when men use Winstrol orally, but these effects are relatively minor when a 2mg/kg dose is being used to increase the effectiveness of other steroids in a cycle. This isn’t carte blanche to go using Winstrol for an extended period of time under the excuse that it’s increasing the overall effectiveness of the cycle. Stanozolol has some of the worst liver toxicity (hepatoxicity) of any oral steroid on a mg for mg basis. In addition, it’s deleterious effects on your lipid profile (Cholesterol) are also very pronounced, even at low doses- 6mgs/day of Stanozolol can lower HDL (good cholesterol)by 33% and raise LDL (bad cholesterol) by 29% (12 ).

So, hopefully, you’ve reached the end of this article and realized that Winstrol can be used in any cycle to increase the effectiveness of it, but that it must be used sparingly due to it’s possible hepatoxicity and lipid profile effecting properties. Still, when used in heavy testosterone-based profiles, at a dose that will cut your SHBG levels in half, it can increase you other steroids effectiveness quite a bit…but when maximal protein synthesis is wanted, you need to inject it.

There you go…the differences between oral and injectable Winstrol, and how you can use either form to maximize your gains! And yes, Lyle, you can drink Winny.


  1. Neural Androgen Receptor Regulation: effects of androgen and antiandrogen. Lu S, Simon NG, Wang Y, Hu S, J Neurobiol 1999 Dec; 41(4):505-12
  2. Endocrinology. 1990 Feb;126(2):1229-34. Xu X, De Pergola G, Bjorntorp P
  3. Endocrinology. 1984 Jun;114(6):2100-6.
  4. Can J Vet Res. 2000 Oct;64(4):246-8.
  5. J Am Vet Med Assoc. 1997 Sep 15;211(6):719-22
  6. MacDonald PC, Madden JD, Brenner PF, Wilson JD, Siiteri PK 1979 Origin of estrogen in normal men and in women with testicular feminization. J Clin Endocrinol Metab 49:905–916
  7. Agents Actions. 1994 Mar;41(1-2):37-43.
  8. Sex Hormone Binding Globulin response to the Anabolic steroid: Stanozolol: Evidence for its suitability as a Biological Androgen Sensitivity test. J Clin Metab Endocrinol 68: 1195, 1989)
  9. The Journal of Clinical Endocrinology & Metabolism Vol. 87,No. 2 530-539. An Effective Hormonal Male Contraceptive Using Testosterone Undecanoate with Oral or Injectable Norethisterone Preparations Axel Kamischke, Tanja Heuermann, Kathrin Krüger, Sigrid von Eckardstein, Ilka Schellschmidt, Alexander Rübig and Eberhard Nieschlag Institute of Reproductive Medicine of the University (A.K., T.H., K.K., S.V.E., E.N.), D-48129 Münster, Germany; and Schering AG (I.S., A.R.), D-13342 Berlin, Germany
  10. Non-sex hormone-binding globulin-bound testosterone as a marker for hyperandrogenism DC Cumming and SR Wall J. Clin. Endocrinol. Metab., Nov 1985; 61: 873 – 876.
  11. Menstrual Irregularity in Women with Acromegaly G. A. Kaltsas, J. J. Mukherjee, P. J. Jenkins, M. A. Satta, N. Islam, J. P. Monson, G. M. Besser, and A. B. GrossmanJ. Clin. Endocrinol. Metab., Aug 1999; 84: 2731 – 2735
  12. JAMA. 1989 Feb 24;261(8):1165-8


Safe Steroid Cycles For Quality Gains: Anavar

An anavar cycle is very exciting for the fatty and bulky people as they can loose large quantities of weight and can also burn  fat very easily but the  true thing is that when one starts to have the cycle then it should be followed properly and in time. In summer, the weight conscious people can go to beach without any hesitation as they can keep themselves cool and without fat as this steroid has the capacity to burn all the fat in the body off these  people. The cutting purpose is possible with the use of the Anavar Cycle and it is the strongest steroid for the production of strength and power in the individual. 

Anavar can help you in regaining  weight and also to burn the weight so we can say it, as the steroid ,offering multipurpose tasks, but what ever one has regained is good weight and not just fat. People who are very skinny can ask the doctor  whether they can use it or not for weight gain because it is very true that once the person regains the weight will not lose it very fast as it’s considered to be  permanent  for sometime. It has the greatest effect on the HPTA, but here the exception is the very low dose. You can often find it for a very reasonable price and is overall the safest drug on the market. Unlike other orals , it’s very unlikely to experience liver toxicity but you always should be monitored by a physician just in case.

There are some people who are using ten mg per day and there are some who are using 50 mg per day, the quantity varies according to the quantity required in the body, but whatever is the case you must be clear about the fact the Anavar cycle is very essential to follow properly.It creates no concept of water retention. The benefits also lies with Oxandrolone but the disadvantage also is there, in the world every thing has its own pros and cons but the best way is to analyze how to use the benefits and how to cross the cons. Regaining of weight and losing of weight comes under the responsibilities of the steroid called Oxandrolone.I would suggest this mild anabolic to anyone that wants to remain safe and produce effective gains that will not put your health in risk. Like I stated earlier, the biggest benefit of this substance is that you will keep most of your gains. When coming off of a powerful anabolic like Testosterone, you will lose alot of what weight you have gained because of water retention.

Anavar Dosages:

Due to its being a mild steroid in every sense of the word, high amounts of Anavar dosage are needed. It binds reasonably well to the AR, but pretty high doses are still needed and I would never suggest doing less than 20mgs/day. In fact, 20-80mgs are needed to start halting AIDS related wasting and recovering weight for burn victims  so that´s the range I´d recommend keeping your dosages in concerning this compound. Personally, I´d use 100mgs/day if I were ever going to try this stuff. Any less than this amount (20-100mgs) would be a waste. For women, however, I think 2.5-10mgs/day would suffice. Virilization is not a concern with this compound, as it is only very mildly androgenic .

Although Anavar is an oral steroid, and has been alpha-alkylated to survive oral ingestion and the first pass through the liver, it´s still relatively mild in that respect too…, the unique chemical configuration of oxandrolone both confers a resistance to liver metabolism as well as noticable anabolic activity. It would also appear that Anavar appears not to exhibit the serious hepatoxic effects (jaundice, cholestatic hepatitis, peliosis hepatis, hyperplasias and neoplasms) typically attributed to the C17alpha-alkylated AASs.  Anavar has even been used successfully in some studies to heal cutaneous wounds , or to improve respiratory function . Both of these novel properties could make it a good choice for in-season use for boxers, Mixed Martial Arts competitors, and other such athletes.

The best advice I can give you is to think about starting off with a small dosage to see how your body responds, if it responds well then try to up the dosa a little bit until you find what works best for you. If you feel comfortable and your health is good, then by all means throw in another compound if you’d like. Just remember always that safety comes first; never put your health at risk for something that can be easily avoidable. Good luck!

Anadrol:Steroid Profile

Oxymetholone is without a doubt one of the strongest and most visibly active steroids to date. Not only does it act very rapidly, it causes a virtual explosion of mass. Gains of up to 10 pounds in 2 weeks are not uncommon. This is largely due to a moderate to low androgenic effect combined with a high anabolic activity also mediated by non-AR mechanisms (mechanisms other than simply binding the androgen receptor). You can imagine that the gains made on oxymetholone aren’t the leanest. You would note a drastic smoothing out of the muscle due to estrogen-related fat (lipolysis) and water retention. This lipolysis has been shown to be rather drastic. One study on long-term hemodialysis patients showed beyond a doubt the role that oxymetholone can play in causing hyperlipedemia. The fat deposition rate, post-hepatic (after processing by the liver), increased drastically in the oxymetholone group while numbers remained stable in the control group.

It has been suggested that the estrogenic effects of oxymetholone may not be as much mediated by estrogen, as by oxymetholone itself activating the estrogen receptor. Because there is little to no aromatisation off oxymetholone, the possible progestational effect was examined first. Similar to that of nandrolone perhaps. But a study2 testing the progestational effects of oxymetholone and methandrostenolone against those of testosterone as well as nandrolone and its metabolites showed that the progestagenic activity of oxymetholone wasn’t even in the neighbourhood of that of testosterone, let alone nandrolone. Ruling out the possibility of progestagenic activity and aromatisation, that only left oxymetholone engaging in a structure with the estrogen receptor itself. Since it has an A-ring similar to that of estradiol (the prime estrogen) so this would be the most logical explanation. Since progesterone acts as an estrogen agonist, it would require circulating estrogen to negotiate such levels of water build-up as oxymetholone causes, so it seemed like a far-fetched idea to begin with.

The water component resulting from oxymetholone use is not be under-estimated either. The benefit of water retention is of course a lubrication of the joints, allowing the comfort of pain-free workouts even with extremely heavy weights, as well as the retention of more nutrients inside the cell, possibly leading to more permanent growth in muscle tissue. The downside to a massive water retention is that it gives you a rather puffed up look. A look not uncommon in off-season competitive bodybuilders and the heaviest classes of powerlifters. With the estrogen increase of course comes the increased risk of more side-effects such as gynocomastia (growth of breast tissue in men). Therefore its always advised that a cycle of oxymetholone is accompanied by the use of an anti-estrogen such as Nolvadex. Nolvadex, keeping in mind that aromatase enzyme is not involved, would be the wiser choice as it blocks the receptor for estrogen rather than the aromatase enzyme. Its wise to note as well that the gains from oxymetholone are largely mediated by estrogen, so reducing estrogen may reduce results as well.

Because it is mild androgen as well as a potent estrogen, blood volume is increased. Androgens raise the red blood cells (although this has been shown to happen through a mechanism other than erythropoesis3) to improve aerobic performance while estrogens increase the white blood cells in an attempt to stimulate the immunity. Couple that increase in blood cells to an increase in water and you get a serious increase in blood volume. This effect has been known to result in magnificent pumps for the users of oxymetholone products. The synthesis of extra erythrocytes (Red blood cells) also increases stamina and performance (this effect is largely negated by the larger estrogenic component. Oxymetholone is not a good product for athletes). Together with the unbelievable strength effect of oxymetholone’s water retention that makes for some incredible workouts. On a side note, these characteristics make for anadrol’s popular use in treating anemia.

The use of oxymetholone should be strict and brief. While it is no doubt the strongest steroid, quantitatively, its also by far the most hazardous steroid to your health. Apart from the great risk of common steroid-related side-effects (acne vulgaris, benign prostate hypertrophy, gynocomastia and androgenetic alopecia), it also has numerous other side-effects. Most notable is oxymetholone’s hepatoxicity (damaging to the liver) : Its standard 17-alpha-alkylated as with most oral steroids, resulting in an inavoidable raise in liver transaminase enzyme counts. The most frequent of the hepatoxic effects is jaundice4 (yellow coloration of the skin) due to an oxymetholone induced increase in biliburine, but others include peliosis hepatis and formation of hepatic tumors (cancer). And that’s not all. There is also a number of intrinsic side-effects noted with the use of this steroid. Headaches, stomach aches, nausea, vomiting, insomnia and diarrhea are among common afflictions associated with oxymetholone use.

This is the reason why only strict doses of oxymetholone are used , often only 1-2 tabs of 50 mg. The general rule of thumb is to use 0.5 or 0.6 mg per pound of bodyweight, most likely putting you in the 100-150 mg range. Because of the negative effects on the liver, its often not used for more than a two or three weeks. The results are fast, but also fleeting and therapy is usually continued with another aromatizable compound, most likely a long acting testosterone like Sustanon or testosterone enanthate. The Anabolic Review also warns that under no circumstances should oxymetholone use exceed 6 weeks. When using oxymetholone, or any oral 17-alpha-alkylated steroid for that matter, one should always consult a physician on a frequent basis and get your liver values checked. Its not that oxymetholone is necessarily more toxic to the liver, but rather that much higher doses are needed than with other oral steroids, so the relative risk increases as well.

Other notes that should be mentioned about this compound are that oxymetholone’s androgenic qualities are not linked to a 5-alpha reduced form. As a matter of fact it shows rather poor interaction with the 5AR enzyme, making it futile to treat a possible increase in hair loss with 5-alpha reductase-blocking products such as finasteride. Its androgenic component stems from the fact that oxymetholone is very much like Dihydrotestosterone were it not for the added 2-hydroxymethylene group. Since this group can be metabolically removed, that would leave methyl-DHT. A compound with a weaker affinity for the androgen receptor than straight DHT, but more active and with less affinity for the DHT-reducing enzyme 3beta hydroxysteroid dehydrogenase. Ultimately resulting in much stronger, instead of weaker androgenic effects than compounds that are actively 5-alpha reduced. This evens out largely, because the distribution is even across the body, where 5-alpha-reduction usually concentrates more potent androgenic forms in androgen responsive tissue such as skin and scalp.

The effect on the blood pressure is rather drastic, so its recommended that you use a anti-hypertensive drug in conjunction, especially if you already have a fairly high blood pressure. Here too the care and control of a physician is advised. Because of the HPTA (hypothalamic-pituitary-testicular axis) suppressive nature, the use of Clomid or Nolvadex and HCG is advised as well towards the end of your oxymetholone use. Lastly, oxymetholone also has an ill effect on the glucose tolerance5, causing borderline diabetic situations. Something to be weary of if you yourself have been diagnosed with similar problems already. In conclusion one can safely state that the negative effects on the system associated with the use of this hormone are rather drastic and that the use is therefore not recommended for beginners, women or people who have pre-existing afflictions. Nonetheless Anadrol remains a popular steroid among experienced users to kick-start a steroid cycle because of its magnificent increases in strength and size. Most people who have used oxymetholone with great success have no problem calling it the strongest and most reliable steroid available today. A somewhat surprising remark however, since Methandrostenolone can produce similar results with half or a third of the doses normally used with oxymetholone and with less side-effects. So personally I would recommend methandrostenolone over oxymethelone, as its clearly stronger, milligram fro milligram. Oxymetholone remains a strong and favorable compound however, despite its side-effects. Its effects may also be slightly more explosive than those of methandrostenolone and therefore people seeking strength may give it an edge over the former.

How To Safely Inject Steroids

All oil based and water based anabolic steroids should be taken intramuscularly. This means the shot must penetrate the skin and subcutaneous tissue to enter the muscle itself. Intramuscular injections are used when prompt absorption is desired, when larger doses are needed than can be given cutaneously or when a drug is too irritating to be given subcutaneously. The common sites for in tramuscular injectons include the buttock, lateral side of the thigh, and the deltoid region of the arm. Muscles in these areas, especially the gluteal muscles in the buttock, are fairly thick. Because of the large number of muscle fibers and extensive fascia, [fascia is a type of connective tissue that surrounds and separates muscles] the drug has a large surface area for absorption. Absorption is further promoted by the extensive blood supply to muscles. Ideally, intramuscular injections should be given deep within the muscle and away from major nerves and blood vessels. The best site for steroid injections is in the gluteus medius muscle which is located in the upper outer quadrant of the buttock. The iliac crest serves as a landmark for this quadrant. The spot for an injection in an adult is usually to 7 1/2 centimeters [2 to 3 inches] below the iliac crest. The iliac crest is the top of the pelvic girdle on the posterior [back] side. You can find the iliac crest by feeling the uppermost bony area above each gluteal muscle. The upper outer quadrant is chosen because the muscle in this area is quite thick and has few nerves. The probability of injecting the drug into a blood vessel is remote in this area. Injecting here reduces the chance of injury to the sciatic nerve which runs through the lower and middle area of the buttock. It controls the posterior of each thigh and the entire leg from the knee down.

If an injection is too close to this nerve or actually hits it, extreme pain and temporary paralysis can be felt in these areas.

This is especially undesirable and warrants staying as far away from this area as possible.

If the gluteal region cannot be injected for some reason, the second choice would be the lateral portion of the thigh. Usually, intramuscular injections in the thigh are only indicated for infants and children. The vastus lateralis muscle is the only area of the thigh that should be injected intramuscularly. This site is determined by using the knee and the greater trochanter of the femur as landmarks. The greater trochanter is the bony area that you can feel where the femur joins the pelvic girdle. The mid portion of the muscle is located by measuring the handbreadth above the knee and the handbreadth below the greater trochanter. Injecting into the front of the thigh or inside of the thigh is extremely unwise. These areas contain nerves as well as a number of blood vessels.

What To Use For Injections

It is important to choose the proper syringe for the administration of injectable anabolic steroids. The principle components of a syringe include a cylindrical barrel to one end of which a hollow needle is attached, and a close fitting plunger. The most acceptable syringe for injecting anabolic steroids is a 22 gauge 1 1/2″ or 23 gauge 1″ apparatus with a 3 cc case. This length allows for penetration to reach deep inside the muscle tissue. Shorter needles, 5/8″ or 1/2″ are usually not sufficient for intramuscular injections and occasionally leave a portion of the Injection in a subcutaneous area which will cause a swell between the skin and muscle as well as impaired absorption. The gauge size of a syringe represents the needle\rquote s diameter. The lower the gauge number, the wider it is. A 27 gauge needle is very thin. An 18 gauge is quite wide; it is often referred to as a cannon. The 22 and 23 gauge needles are not so large that they are difficult to insert, yet are large enough for solutions to easily be propelled through them. The use of insulin needles is not acceptable; they are simply too small. Usually, insulin pins are 25 to 27 gauge and only a 1/2″ long with a 1 cc case.

Injection Procedures

There are a number of steps that should be understood in order to complete a safe and proper intramuscular injection. First off, before handling any needles or vials, the user should take a thorough shower. Next, an alcohol swab should be used to clean the injection site and another alcohol swab should be used to clean the rubber stopper on top of the vial which will be drawn from. Then, take a brand new syringe out of its wrapper, remove its plastic top, draw about 2 ccs of air into it and insert it into the vial. Inject this air into the vial; this creates pressure within the vial and makes it easier to draw out oil based preparations. Then, turn the vial upside-down and slowly draw out the oil until you\rquote ve overdrawn at least 1/4 cc. For example, if someone was going to take a shot of 1 cc, they should pull out approximately 1 1/4 to 1 1/2 ccs of liquid, then tap the side of the case to help get the air bubbles that were drawn into the syringe to come to the top. At that point, the excess 1/4 to 1/2 cc could be injected back into the vial and the needle removed. Then, hold the syringe needle-side-up and continue to tap it to encourage all the air bubbles to come to the top of the syringe. Now, take another clean syringe, remove it from its sterile package and unscrew the needle from the syringe. Exchange the brand new needle for the one that has just been injected into the stopper. By using two needles for every injection, you can take advantage of using the full sharpness of the pin. The needle does suffer some dulling when it is pushed through the firm rubber stopper on a vial. It is important not to touch this needle before the injection. It should not come into contact with a counter top, your fingers, nor should it be cleaned with alcohol. This needle is sterile and should not be touched. At this point, once again swab the injection site with alcohol, then press the stopper of the syringe holding it needle-side-up, until the slight air bubbles that are at the top are pressed out. Once a bead of oil has appeared at the top of the needle, allow it run down the surface of the needle which provides lubrication. At this time, take the syringe and hold it like a dart. Use the other hand to stretch the skin at the injection site and simply push the sharp clean needle in. After inserting it deep into the muscle, pull back on the stopper for a few seconds to make sure it does not fill up with blood which would indicate that the needle had been injected into a blood vessel. Providing there is no blood present in the syringe, slowly press the stopper down until all the oil is injected. Then, quickly pull the needle out and take another alcohol swab and press firmly on the injection site. This will minimize bleeding, if there is any, and by firmly pressing on the injection site and slightly massaging it, some of the soreness may be eliminated. It is important that the liquid is not injected too quickly as this causes more pain at the site during the injection and in the proceeding days. After this procedure has been completed, return the plastic caps to shield the needles and make sure they are discarded properly. To avoid discomfort and excessive scar tissue at the injection site, it is not wise to inject more than 2 ccs of solution per shot. It is also not prudent to use the same injection site more than twice a week [once a week is preferred].

Why Some Steroid Shots Hurt?

High Mg per ML Roids, What you need to know ?

1. Most hormones have a pretty low solubility in oil.
2. The primary ways to increase solubility are to
A) add solvent (BA or EA).
B) Add an ester to the hormone. The longer the ester
the more hormone will fit in the oil at a certain mg
per ml ratio. Conversely, the weight of the ester is
also factored in the total mg per ml ratio, so while
you can fit more hormone in, you are getting less

actual hormone than the mg amount implies. Here are
some examples:

Ester actual mg/100mg dose
test no ester 100
tren acetate 87
test prop 83
test enanth 72
test cyp 70
test undecan 63
nand phenyl 67
nand deca 64

This means that if your test cyp says 200 mgs per ml
you get an actual 140 mgs of test. The rest of the
weight is the weight of the ester. If that sounds like
a bad deal you need to understand that test no ester
is VERY insoluble in oil without going to very high mg
per ml solvent concentrations.

This brings up the next point; PAIN!

Why do some shots hurt? There are two primary reasons.
One, the solvent ratio is too high. Anything over
about 10% starts to hurt. BA and EA are VERY
inflammatory to the tissues. That?s why you want ONLY
enough to help your oil hold more gear but not so much
that it causes inflammation.

The second reason is that the gear crystallizes in the
depot. This is precisely why water-based suspensions
feel like hammer blows. The water is absorbed FAST,
leaving the gear to crystallize in the tissues = PAIN.
Even gear in oil can do this, here is how it works. If
you use a low ester weight attached to your gear and
make the mg per ml ratio SIGNIFICANTLY higher than the
oil will hold on it’s own, what happens is the body
absorbs the solvent faster than the oil/gear and the
gear falls out of the solution and crystallizes in the
depot and WHAM, it hurts like hell. An optimum
solution has just enough solvent to get more gear into
solution than you could otherwise, but not so much
that what I just stated happens. When the ratios are
correct the gear holds in the solution UNTIL the whole
depot is absorbed and very little or no pain is felt.
Just to end this misconception once and for all IT IS
cc’s of sterile oil and never know you took a shot. It
IS NOT HOW MUCH OIL YOU SHOOT! So why does everyone
search for super high mg per ml ratio gear like it’s
the damn holy grail???

What is too high?

Well the length of the ester is
really what determines that but most of us here know
the gear that hurts and know we know why. All tests
over 250 mgs per ml hurt, and actually most of the 250
mg tests hurt too. SOOOO many people want there tren
at 150-200 mgs per ml. Tren acetate should be at about
what?? 75 mgs per ml. That is why all the kits are
designed this way. Do you really think it’s cheaper
for the kit producers to add MORE oil to their kits
instead of less? One other quick note. Oil is used
because it SLOWS absorption. THIS IS PRECISELY WHAT
YOU WANT IN A STEROID SHOT! Less oil does not promote
the steady state hormone levels achieved with more oil.

Steroid Esters

Testosterone Suspension- this drug is pure testosterone in sterilized water. There is no ester attached and the testosterone is biologically active at 100%, upon injection. The testosterone is suspended in tiny crystals within the aqueous solution which is why the “suspension sting” occurs upon injection. The crystals begin to dissolve very rapidly upon injection (there is no added partition coefficient because there is no ester attached slowing the absortption of the drug). One hundred milligrams (100mg) of testosterone suspension, is, literally 100mg of active drug. The half-life of the drug is from 12-36 hours depending on the state of your metabolism and the prescense of other drugs (more on this later).

Testosterone Propionate- this is also one of the most popular testosterone esters around and has the shortest available ester chain available in an injectable testosterone product. We have previously stated that the ester chain of prop is three carbons long. The ester is taken from propionic acid, which is an acid that has the potential to irritate the injected muscle. Often prop is used for site injection due to the fact that it causes an intense localized swelling of the injection site in most users. The reason prop stings is due to the short ester chain. Generally, the shorter the ester, the more irritation to the muscle. For example, bee venom, is C1, prop is C3 (three carbon chain). Make sense right? The half-life of testosterone propionate is on the order of 48-72 hours, or two to three days. The disadvantage to using shorter chain esters is the need to inject more frequently and the general pain from the injections. Advantages include a quicker onset of action, and more immediate effects.

An interesting side note is that the smaller ester chains, weigh less. This is important because it brings another advantage of shorter chain ester drugs to the table. If the ester weighs less, the amount of testosterone per milliliter or cubic centimeter (cc, they are interchangeable) is more. For example, testosterone suspension is 100% testosterone as we have said previously. It has no ester. The short chain ester propionate, is roughly 74% testosterone. This means that if you take a typical 1cc shot of prop at 100mg/cc, this is actually 74mg of testosterone and 26 milligrams of ester weight. A larger ester such as enanthate, is roughly 55% testosterone. Twenty-eight (45%) percent of the gross weight of a given amount of testosterone enanthate is the actual enanthate ester, not the active testosterone that you are searching for. So, a typical 200mg/cc shot of enanthate only contains 110mg of active testosterone. If you have ever used a shorter acting injectable anabolic, and gotten better results than using heavier dosages of longer acting drugs, this is the reason. You may have been getting more “active” drug into your system with what appeared to be less “overall” or gross mg dosage of drug.

A great illustration of the above point is evident when comparing the “active” amount of testosterone yield in equal “mg” dosages of these two testosterone esters. Think of the 110mg/200mg injection of enanthate. The 74mg/100mg injection of propionate would yield more active testosterone if you were to take “200mg) of the drug. This would yield 148mg of testosterone from the propionate!! Do you see? So, 200mg of propionate is more “active” test than 200mg of enanthate.

Yet another factor to consider is that you have more drug interacting with receptors at a given time with shorter acting drugs. It is essential to understand drug half life if you are to get the most “bang for your buck” from anabolics. With respect to your health and longevity, this is also of paramount importance. Why take more, if less works just as well. As we will explore, sometimes, less works even better.

Testosterone Enanthate- enth for short is one of the most readily available testosterones on the market. Even those without significant connections can usually find some enth. The half life of enth as many of my buddies call it, ranges in the literature between 4-7 days. For our purposes, it is fair to figure a little under a week’s time. Testosterone enanthate is not known to cause extreme irritation at injection sites and is a good staple drug to build quality mass with if you are not overly susceptible to estrogenic affects. Testosterone enanthate is a good cheap drug that can fulfill the androgenic component of a cycle many times over. If you want a high and consistent blood level of testosterone and don’t want to constantly poke yourself, testosterone enanthate is a quality choice. One poke every four to five days is a good frequency to maintain blood levels. Whatever amount you choose to do will be fine on this schedule, i.e. it will maintain the blood level well because you are taking another dosage before the hal-life has a chance to cut the blood level back down.

Keep in mind that using enanthate this way will cause a significant build up of testosterone in the bloodstream that will not cease to increase until four or five weeks of injections. This is due to the fact that taking a four hundred milligram injection, and another four days later, still has at least 200mg working from the previous dose. The third injection then adds another four hundred and the first is still not entirely used up. You may realistically have over a gram or so in the bloodstream before you know it. Just be careful, and keep this in mind when figuring out your dosages.

Testosterone Cypionate- testosterone cypionate or cyp is closely interchangeable with enanthate. They differ by one carbon chain length which does not significantly affect the duration of action of these drugs. Cypionate has one more carbon in the ester chain attachment than does enanthate, so technically, equal dosages of enanthate or cypionate will yield a slightly higher amount of testosterone from the enanthate ester.

There are many possible chemical combinations of testosterone. Scientists can do amazing things. The above esters are the most common drug esters used in our community of drug enhancement.

This is just the enanthate ester, without the testosterone molecule. This is the plain testosterone molecule: If you attach the enanthate ester to the 17th position (technically 17-beta position as scientists like to call it), you create the testosterone enanthate molecule/structure.
Don’t worry about the details of all this. Just want to show you what enanthate looks like. Some muscle nerds like myself actually dig this stuff. Check out the drug profiles section for the other testosterone esters such as propionate, cypionate, etc., and just be aware that the roof top position of the fourth ring (17th position) is where all the action takes place (where the esters are located as well as where the methyl group is placed to make anabolics orally active-we’ll get to that).

Steroid Effectiveness Chart

This is a steroid effective chart for those of you wondering:HIGH  10
LOW    1

Trade Name Chemical Name Weight Gain Strength Gain Fat Loss Side Effects
Anadrol Oxymetholone 10 10 2 10
Anavar Oxandrolone 2 8 8 2.5
Andriol Testosterone Undecanoate 3 4 4 2
Androgel Testosterone (Crème) 3 4 3 2
Boldenone (esterless) Boldenone 5 7 5 4
Cheque Drops Mibolerone 1 5 1 6
Deca-Durabolin Nandrolone Decanoate 7 6 5 6
Equipoise Boldenone Undeclynate 5 7 5 4
Halotestin Fluoxymesterone 1 6 5 6
Laurabolin Nandrolone Laurate 7 6 5 6
Masteron Drostanolone Propionate 3 6 6.5 3
Masteron Enanthate Drostanolone Enanthate 3 6 6.5 3
Methyltestosterone Methyltestosterone 2 6 4 7
Omnadren Testosterone Blend 8 8 4 6
Oral-Turinabol 4-chlorodehydro methyltestosterone        
Parabolan Trenbolone Hexahydrobencylcarbonate 5 7 8 7
Primobolan (Injectable) Methenolone Enanthate 4 6 7 1
Primobolan (oral) Methenolone Acetate 4 5 5 3
Proviron Mesterolone 2 4 4 2
Sten Testosterone Blend 8 8 4 6
Sustanon Testosterone Blend 8 8 4 6
Test 400 (T400) Testosterone Blend 8 8 4 6
Testolent Testosterone Phenylpropionate 8 8 4 6
Testosterone Cypionate Testosterone Cypionate 8 8 4 6
Testosterone Enanthate Testosterone Enanthate 8 8 4 6
Testosterone Propionate Testosterone Propionate 8 8 4 6
Testosterone Suspension Testosterone Suspension 9 8 4 6
Testoviron Testosterone Blend 8 8 4 6
Trenbolone Acetate Trenbolone Acetate 5 7 8 7.5
Trenbolone Enanthate Trenbolone Enanthate 5 7 8 7
Winstrol Stanozolol 4 6.5 7 6.5
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